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NSMAF Antibody

NSMAF Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameNSMAF Primary Polyclonal Antibody
Also known asNSMAF PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenNSMAF
SpecificityThis is a highly specific antibody against NSMAF
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NSMAF
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiate TNF signaling events, FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction, N-SMase has been shown to be involved in TNF-induced Raf-1 activation (6), The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5), The majority of TNF functions are primarily mediated through TNF-R1 (1, These receptors, are expressed on most cell types (1, designated TNF-R1 and TNF-R2, which results in the initiation of the N-SMase pathway (5), 2), 3), 4), Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FAN, Factor associated with neutral sphingomyelinase, Factor associated with neutral sphingomyelinase activation, Neutral sphingomyelinase N SMase activation associated factor, Protein FAN, Factor associated with N SMase activation
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetNSMAF
Short nameNSMAF Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameNSMAF (Antibody to)
Alternative techniqueantibodies
Identity 8017
Gene NSMAF
Long gene name neutral sphingomyelinase activation associated factor
Synonyms gene name neutral sphingomyelinase (N-SMase) activation associated factor
Synonyms FAN GRAMD5
Locus 8q12, 1
Discovery year 1998-11-04
GenBank acession X96586
Entrez gene record 8439
Pubmed identfication 8808629 10640829
RefSeq identity NM_003580
Classification BEACH domain containing GRAM domain containing WD repeat domain containing
Havana BLAST/BLAT OTTHUMG00000164352

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