| Long name | 1) Monoclonal Antibody, 6, NTRK1 (185CT47 |
| Also known as | 1) Monoclonal Antibody, 6, NTRK1 (185CT47 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | NTRK1 |
| Specificity | This is a highly specific antibody against NTRK1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 1, 185CT47, 6 |
| Source | This NTRK1 Monoclonal antibody was raised using purified His-tagged recombinant human NTRK1 |
| Gene ID number | 4914 |
| Swiss Prot | P04629 |
| Tested Applications | WB |
| Recommended dilutions | WB(1:500~4000) |
| Cross reactivity | Mouse, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation, FRS2, High affinity receptor for NGF which is its primary ligand, However, In absence of ligand and activation, Isoform TrkA-III is resistant to NGF, Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival, Recruits, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation, Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival, Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival, Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival, Upon dimeric NGF ligand-binding, autophosphorylation and activation, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade, differentiation and survival of sympathetic and nervous neurons, it can also bind and be activated by NTF3/neurotrophin-3, making the survival of neurons dependent on trophic factors, may promote cell death, phosphorylates and/or activates several downstream effectors including SHC1, undergoes homodimerization, Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation |
| Purification method | 09% (W/V) sodium azide, Mouse monoclonal antibody supplied in crude ascites with 0 |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1, TRK1-transforming tyrosine kinase protein, TRKA, Trk-A, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp140trk, p140-TrkA, MTC |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 1) Monoclonal, 6, NTRK1 (185CT47 |
| Short name | 1) Monoclonal Antibody, 6, NTRK1 (185CT47 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | classification 1 (185CT47, receptor, 1) monoclonal (Antibody to), 6, neurotrophic tyrosine kinase |
| Alternative technique | antibodies |
| Alternative to gene target | BT, Cell surfaces, MTC and p140-TrkA and TRK and Trk-A and TRK1 and TRKA, NTRK1 and IDBG-103632 and ENSG00000198400 and 4914, Ntrk1 and IDBG-158646 and ENSMUSG00000028072 and 18211, glutamatergic and biological process this GO :0060009 and Sertoli cell development and biological process this GO :0060385 and axonogenesis involved in innervation and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0071316 and cellular response to nicotine and biological process this GO :0071363 and cellular response to growth factor stimulus and biological process this GO :1901215 and negative regulation of neuron death and biological process this GO :1990090 and cellular response to nerve growth factor stimulus and biological process, receptor, this GO :0000186 and activation of MAPKK activity and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005030 and neurotrophin receptor activity and molecular function this GO :0005166 and neurotrophin p75 receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005768 and endosome and cellular component this GO :0005769 and early endosome and cellular component this GO :0005770 and late endosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007190 and activation of adenylate cyclase activity and biological process this GO :0007202 and activation of phospholipase C activity and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007399 and nervous system development and biological process this GO :0007411 and axon guidance and biological process this GO :0007568 and aging and biological process this GO :0007611 and learning or memory and biological process this GO :0007623 and circadian rhythm and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009314 and response to radiation and biological process this GO :0009986 and cell surface and cellular component this GO :0010465 and nerve growth factor receptor activity and molecular function this GO :0010623 and developmental programmed cell death and biological process this GO :0010976 and positive regulation of neuron projection development and biological process this GO :0014823 and response to activity and biological process this GO :0016772 and transferase activity, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004714: transmembrane receptor protein tyrosine kinase activity and also this GO :0005030: neurotrophin receptor activity and also this GO :0005166: neurotrophin p75 receptor binding and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0010465: nerve growth factor receptor activity and also this GO :0016772: transferase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004714: transmembrane receptor protein tyrosine kinase activity, this GO :0005030: neurotrophin receptor activity, this GO :0005166: neurotrophin p75 receptor binding, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0010465: nerve growth factor receptor activity, this GO :0016772: transferase activity, this GO :0042803: protein homodimerization activity, this GO :0043121: neurotrophin binding, this GO :0046875: ephrin receptor binding, this GO :0048406: nerve growth factor binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0042803: protein homodimerization activity and also this GO :0043121: neurotrophin binding and also this GO :0046875: ephrin receptor binding and also this GO :0048406: nerve growth factor binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019233 and sensory perception of pain and biological process this GO :0021553 and olfactory nerve development and biological process this GO :0030183 and B cell differentiation and biological process this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0031667 and response to nutrient levels and biological process this GO :0031901 and early endosome membrane and cellular component this GO :0031902 and late endosome membrane and cellular component this GO :0032320 and positive regulation of Ras GTPase activity and biological process this GO :0035094 and response to nicotine and biological process this GO :0038179 and neurotrophin signaling pathway and biological process this GO :0038180 and nerve growth factor signaling pathway and biological process this GO :0042490 and mechanoreceptor differentiation and biological process this GO :0042493 and response to drug and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043025 and neuronal cell body and cellular component this GO :0043068 and positive regulation of programmed cell death and biological process this GO :0043121 and neurotrophin binding and molecular function this GO :0043234 and protein complex and cellular component this GO :0043235 and receptor complex and cellular component this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0045471 and response to ethanol and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0046579 and positive regulation of Ras protein signal transduction and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046875 and ephrin receptor binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048406 and nerve growth factor binding and molecular function this GO :0048485 and sympathetic nervous system development and biological process this GO :0048678 and response to axon injury and biological process this GO :0050965 and detection of temperature stimulus involved in sensory perception of pain and biological process this GO :0050966 and detection of mechanical stimulus involved in sensory perception of pain and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051599 and response to hydrostatic pressure and biological process this GO :0051602 and response to electrical stimulus and biological process this GO :0051968 and positive regulation of synaptic transmission, type 1, 22873 and IDBG-631386 and ENSBTAG00000003060 and 353111, neurotrophic tyrosine kinase |
| Identity | 8031 |
| Gene | NTRK1 |
| Long gene name | neurotrophic receptor tyrosine kinase 1 |
| Synonyms gene name | neurotrophic tyrosine kinase, receptor, type 1 |
| Synonyms | TRK TRKA MTC |
| Synonyms name | high affinity nerve growth factor receptor |
| Locus | 1q23, 1 |
| Discovery year | 1991-07-18 |
| GenBank acession | Y09028 |
| Entrez gene record | 4914 |
| Pubmed identfication | 2869410 |
| RefSeq identity | NM_002529 |
| Classification | Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT | OTTHUMG00000041304 |
| Locus Specific Databases | Inherited Peripheral Neuropathies Mutation Database LRG_261 |
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