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NTRK2 (1446CT494.85.83.49) Monoclonal Antibody

NTRK2 (1446CT494.85.83.49) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name49) Monoclonal Antibody, 83, 85, NTRK2 (1446CT494
Also known as49) Monoclonal Antibody, 83, 85, NTRK2 (1446CT494
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenNTRK2
SpecificityThis is a highly specific antibody against NTRK2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1446CT494, 49, 83, 85
SourceThis NTRK2 antibody is generated from a mouse immunized with a recombinant protein
Gene ID number4915
Swiss ProtQ16620
Tested Applications FCM, IHC-P, WB
Recommended dilutions FC(1:25), WB(1:1000), IHC-P(1:25)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2, FRS2, FRS2, Hence, May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia, PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival, Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4, Recruits, SH2B1, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades, Thereby, Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity, Through SHC1, Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival, Upon ligand-binding, and synapse formation and plasticity, autophosphorylation and activation, differentiation, it is able to suppress anoikis, migration, phosphorylates and/or activates several downstream effectors including SHC1, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation, proliferation, the apoptosis resulting from loss of cell-matrix interactions, undergoes homodimerization, Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names BDNF/NT-3 growth factors receptor, GP145-TrkB, NTRK2, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B, trk-B, TRKB
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target49) Monoclonal, 83, 85, NTRK2 (1446CT494
Short name49) Monoclonal Antibody, 83, 85, NTRK2 (1446CT494
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name49) monoclonal (Antibody to), 83, 85, NTRK2 (1446CT494
Alternative techniqueantibodies
Identity 8032
Gene NTRK2
Long gene name neurotrophic receptor tyrosine kinase 2
Synonyms gene name neurotrophic tyrosine kinase, receptor, type 2
Synonyms TRKB
Locus 9q21, 33
Discovery year 1991-07-18
GenBank acession AF410902
Entrez gene record 4915
Pubmed identfication 7789988
Classification I-set domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000020120

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