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Oncostatin M Antibody / OSM

Oncostatin M Antibody / OSM size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenOncostatin M / OSM
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC-P, WB
Recommended dilutions1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0
NotesOptimal dilution of the OSM antibody should be determined by the researcher
Intented useThis OSM antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P13725
PurityAntigen affinity
Description CSF3, G-CSF and GM-CSF from endothelial cells, It has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts, It regulates cytokine production, Oncostatin M also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, The OSM gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines, The direction of gene transcription was telomeric to centromeric, Treatment with recombinant Oncostatin M leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types, a function shared by LIF, and IL6, and interleukin 6, granulocyte colony-stimulating factor, including IL-6, with the OSM gene located upstream of the LIF gene, Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor
ImmunogenAmino acids 26-220 of human Oncostatin M were used as the immunogen for the OSM antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the OSM antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
Localization cytoplasmic, Nuclear
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetOncostatin M / OSM
Short nameOncostatin M Antibody / OSM
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameOncostatin M (Antibody to) / oncostatin M
Alternative techniqueantibodies
Alternative to gene target BT, Extracellular, OSM and IDBG-4002 and ENSG00000099985 and 5008, Osm and IDBG-142284 and ENSMUSG00000058755 and 18413, growth factor activity, this GO :0002675 and positive regulation of acute inflammatory response and biological process this GO :0005125 and cytokine activity and molecular function this GO :0005147 and oncostatin-M receptor binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005900 and oncostatin-M receptor complex and cellular component this GO :0006955 and immune response and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007422 and peripheral nervous system development and biological process this GO :0008083 and growth factor activity and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009408 and response to heat and biological process this GO :0033138 and positive regulation of peptidyl-serine phosphorylation and biological process this GO :0040008 and regulation of growth and biological process this GO :0042503 and tyrosine phosphorylation of Stat3 protein and biological process this GO :0042506 and tyrosine phosphorylation of Stat5 protein and biological process this GO :0042508 and tyrosine phosphorylation of Stat1 protein and biological process this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0045835 and negative regulation of meiosis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046888 and negative regulation of hormone secretion and biological process this GO :0048266 and behavioral response to pain and biological process this GO :0050731 and positive regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0051781 and positive regulation of cell division and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, this GO :0005125: cytokine activity, this GO :0005125: cytokine activity and also this GO :0005147: oncostatin-M receptor binding and also this GO :0008083: growth factor activity, this GO :0005147: oncostatin-M receptor binding, this GO :0008083: growth factor activity, 45038 and IDBG-636338 and ENSBTAG00000016163 and 319086, oncostatin M
Identity 8506
Gene OSM
Long gene name oncostatin M
Synonyms MGC20461
Locus 22q12, 2
Discovery year 1992-07-09
GenBank acession AF129855
Entrez gene record 5008
Pubmed identfication 1717982
RefSeq identity NM_020530
Classification Interleukin 6 cytokine family
Havana BLAST/BLAT OTTHUMG00000150913

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