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Optineurin Antibody

Optineurin Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameOptineurin Primary Polyclonal Antibody
Also known asOptineurin PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenOptineurin
SpecificityThis is a highly specific antibody against Optineurin
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range350-400/577
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Optineurin
Gene ID number10133
Swiss ProtQ96CV9
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity Mouse, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family, Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation, May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD), May constitute a cellular target for adenovirus E3 14, Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, Negatively regulates the induction of IFNB in response to RNA virus infection, Plays a neuroprotective role in the eye and optic nerve, Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death, an inhibitor of TNF-alpha functions, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52, in exocytosis, in membrane trafficking, regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment, such as cytoplasmic Salmonella enterica, such as of transferrin receptor (TFRC/TfR), targets ubiquitin-coated bacteria (xenophagy), thereby affecting cell death, through its interaction with myosin VI and Rab8, 7, Plays an important role in the maintenance of the Golgi complex
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ALS12, E3-14, FIP-2, FIP2, GLC1E, HIP-7, HIP7, HYPL, Huntingtin yeast partner L, Huntingtin-interacting protein 7, Huntingtin-interacting protein L, NEMO-related protein, OPTN, Optic neuropathy-inducing protein, Optineurin, TFIIIA-INTP, Transcription factor IIIA-interacting protein, 7K-interacting protein, NRP
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetOptineurin
Short nameOptineurin Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameOptineurin (Antibody to)
Alternative techniqueantibodies
Identity 17142
Gene OPTN
Long gene name optineurin
Synonyms gene GLC1E
Synonyms gene name E (adult-onset) , glaucoma 1, open angle
Synonyms FIP2 HYPL FIP-2 TFIIIA-INTP NRP HIP7
Locus 10p13
Discovery year 2001-11-16
GenBank acession AF420371
Entrez gene record 10133
Pubmed identfication 11834836 9488477
RefSeq identity NM_021980
Havana BLAST/BLAT OTTHUMG00000017690
Locus Specific Databases ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

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