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p-Rb Antibody (pS249)

p-Rb Antibody (pS249) size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenp-Rb (pS249)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:50-1:100, Western blot: 1:1000
NotesTitration of the p-Rb antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis phospho-p-Rb antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P06400
PurityAntigen affinity
Description Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma, Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), It forms a complex with adenovirus E1A and with SV40 large T antigen, RB1 is a potent inhibitor of E2F-mediated trans-activation, This protein inhibits the intrinsic kinase activity of TAF1, a congenital malignant tumor that arises from the nuclear layers of the retina, acts as a tumor suppressor, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding, RB1 likely acts as a regulator of other genes
ImmunogenThis p-Rb antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS249 of human Retinoblastoma
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the p-Rb antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetp-Rb (pS249)
Short namep-Rb Antibody (pS249)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namep-Rb (Antibody to) (pS249)
Alternative techniqueantibodies

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