Filters

P105 RB Antibody, FITC Conjugated

P105 RB Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, P105 RB Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenP105 RB
SpecificityThis is a highly specific antibody against P105 RB
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range68-116/928
Subcellular locationNucleus
SourceKLH conjugated synthetic peptide derived from human Rb/P105 RB
Gene ID number5925
Swiss ProtP06400
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts as a transcription repressor of E2F1 target genes, Controls histone H4 'Lys-2' trimethylation, Directly involved in heterochromatin formation by maintaining overall chromatin structure and, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity, In case of viral infections, In resting neurons, Inhibits the intrinsic kinase activity of TAF1, Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter, Promotes G-G1 transition when phosphorylated by CDK3/cyclin-C, RB1 is dephosphorylated by calcineurin, Recruits and targets histone methyltransferases SUV39H1, SUV42H1 and SUV42H2, The underphosphorylated, Upon calcium influx, active form of RB1 interacts with E2F1 and represses its transcription activity, in particular, interactions with SV4 large T antigen, leading to cell cycle arrest, leading to epigenetic transcriptional repression, that of constitutive heterochromatin by stabilizing histone methylation, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex, which leads to release of the repressor complex (By similarity), Key regulator of entry into cell division that acts as a tumor suppressor
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms LYT-10 p52 p105 NF-kB2 p49/p100
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetP105 RB Conjugated
Short name FITC Conjugated, P105 RB Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, P105 RB (Antibody to)
Alternative techniqueantibodies
Identity 7795
Gene NFKB2
Long gene name nuclear factor kappa B subunit 2
Synonyms gene name nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Locus 10q24, 32
Discovery year 1991-11-14
GenBank acession X61498
Entrez gene record 4791
Pubmed identfication 1876189
Classification Ankyrin repeat domain containing NF-kappa B complex subunits
Havana BLAST/BLAT OTTHUMG00000018962

Similar products

Subscribe to our Newsletter