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p130 Antibody RBL2

p130 Antibody RBL2 size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenp130 RBL2
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
Notes Titration of the p130 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis p130 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q08999
PurityAntigen affinity
Description Based on known syntenic relationships among human, Deletions of chromosome 16q have been found in several human neoplasms, In contrast, It is also known as Retionblastoma-related gene (RB2) and p130, Kong et al, Williams et al, Yeung et al, and prostate cancers, hepatic, including breast, ovarian, p107(RBL1) -/- and p130(RBL2) -/- fibroblasts were more susceptible to HRAS-mediated transformation than wildtype cells, rat and mouse, respectively, the data suggested that the mouse homolog resides on chromosome 8, using fluorescence in situ hybridization and somatic hybrid cell analysis, which supports the involvement of RBL2/p130 in human cancer as a tumor suppressor gene, with loss of either protein leading to longer telomeres, (1993) mapped the RBL2 gene to human chromosome 16q12, (2006) found that mouse fibroblasts lacking Rb were less susceptible to an oncogenic HRAS allele than wildtype cells, (2006)found that RBL2 and RINT1 were essential for telomere length control in human fibroblasts, 2 and rat chromosome 19, Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene
ImmunogenAn amino acid sequence from the C-terminus of human p130 (ENHSALLRRLQDVANDRGSH) was used as the immunogen for this p130 antibody (100% rat homology)
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the p130 antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetp130 RBL2
Short namep130 Antibody RBL2
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namep130 (Antibody to) RBL2
Alternative techniqueantibodies
Identity 9894
Gene RBL2
Long gene name RB transcriptional corepressor like 2
Synonyms gene name retinoblastoma-like 2
Synonyms Rb2 p130
Locus 16q12, 2
Discovery year 1994-01-17
GenBank acession X74594
Entrez gene record 5934
Pubmed identfication 8361765 8643454
RefSeq identity NM_005611
Havana BLAST/BLAT OTTHUMG00000133198

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