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p19ARF Antibody

p19ARF Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namep19ARF Primary Polyclonal Antibody
Also known asp19ARF PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target Antigenp19ARF
SpecificityThis is a highly specific antibody against p19ARF
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human P19ARF
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Rat, Mouse
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a tumor suppressor, Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes, Binds to BCL6 and down-regulates BCL6-induced transcriptional repression, Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression, Binds to HUWE1 and represses its ubiquitin ligase activity, Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus, Binds to TOP1/TOPOI and stimulates its activity, Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1, May play a role in controlling cell proliferation and apoptosis during mammary gland development, This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation, This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis, thus inhibiting rRNA processing, P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Cdkn2a, isoform 2, p19ARF, Cyclin-dependent kinase inhibitor 2A
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetp19ARF
Short namep19ARF Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namep19ARF (Antibody to)
Alternative techniqueantibodies
Identity 1787
Gene CDKN2A
Long gene name cyclin dependent kinase inhibitor 2A
Synonyms gene CDKN2 MLM
Synonyms gene name cyclin-dependent kinase inhibitor 2A (melanoma, inhibits CDK4) , p16
Synonyms CDK4I p16 INK4a MTS1 CMM2 ARF p19 p14 INK4 p16INK4a p19Arf p14ARF
Locus 9p21, 3
Discovery year 1994-05-19
GenBank acession L27211
Entrez gene record 1029
Pubmed identfication 8152487 7606716
RefSeq identity NM_000077
Havana BLAST/BLAT OTTHUMG00000019686
Locus Specific Databases LOVD - Leiden Open Variation Database LRG_11

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