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p53 (AF2C1) Monoclonal Antibody

p53 (AF2C1) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namep53 (AF2C1) Monoclonal Antibody
Also known asp53 (AF2C1) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target Antigenp53
SpecificityThis is a highly specific antibody against p53
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone numberAF2C1
Concentration1ug per 1ul
SourceRecombinant human protein purified from E, coli (His-p53)
Gene ID number7157
Swiss ProtP04637
Tested Applications IP, WB
Recommended dilutions0 ug), 5 ug/ml) IP (2, WB (0
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, Implicated in Notch signaling cross-over, In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1, Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process, Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters, Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1, Isoform 7 inhibits isoform 1-mediated apoptosis, LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation, One of the activated genes is an inhibitor of cyclin-dependent kinases, Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492), induces growth arrest or apoptosis depending on the physiological circumstances and cell type, or by repression of Bcl-2 expression, the function is largely independent of transcription, thus stopping cell cycle progression, Acts as a tumor suppressor in many tumor types
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, LFS1, Phosphoprotein p53, TP53, TRP53, Tumor suppressor p53, P53
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetp53 (AF2C1) Monoclonal
Short namep53 (AF2C1) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative namep53 (AF2C1) monoclonal (Antibody to)
Alternative techniqueantibodies

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