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p53 Antibody (phospho-S315)

p53 Antibody (phospho-S315) size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration09% sodium azide, 4 with 0, In 1X PBS pH 7
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenp53 (phospho-S315)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, DB
Recommended dilutionsDot blot: 1:500, IHC (Paraffin): 1:50-1:100
NotesTitration of the phospho-p53 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis phospho-p53 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P04637
PurityAntigen affinity
Description Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, It is found in very low levels in normal cells, It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, a nuclear protein, and believed to contribute to transformation and malignancy, and hence cause the loss of tumor suppressor activity, and thus function as a tumor suppressor, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome, however, in a variety of transformed cell lines, it is expressed in high amounts, oligomerization and transcription activation domains, p53 is a DNA-binding protein containing DNA-binding, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1, Tumor protein p53
ImmunogenThis phospho-p53 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS315 of human p53
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the phospho-p53 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetp53 (phospho-S315)
Short namep53 Antibody (phospho-S315)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namep53 (Antibody to) (phosphorilated-S315)
Alternative techniqueantibodies

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