Filters

P53 protein(wt-p53) Antibody

P53 protein(wt-p53) Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameP53 protein(wt-p53) Primary Polyclonal Antibody
Also known asP53 protein(wt-p53) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenP53 proteinwt-p53
SpecificityThis is a highly specific antibody against P53 proteinwt-p53
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range240-290/393
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human P53
Gene ID number7157
Swiss ProtP04637
Tested Applications IF(ICC), IF(IHC-P), IHC-P, WB
Recommended dilutions IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, Implicated in Notch signaling cross-over, In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1, Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process, Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters, Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1, Isoform 7 inhibits isoform 1-mediated apoptosis, LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation, One of the activated genes is an inhibitor of cyclin-dependent kinases, Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, induces growth arrest or apoptosis depending on the physiological circumstances and cell type, or by repression of Bcl-2 expression, the function is largely independent of transcription, thus stopping cell cycle progression, Acts as a tumor suppressor in many tumor types
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, LFS1, Phosphoprotein p53, TP53, TRP53, Tumor suppressor p53, P53
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetP53 protein(wt-p53)
Short nameP53 protein(wt-p53) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameP53 protein(wt-p53) (Antibody to)
Alternative techniqueantibodies
Identity 11998
Gene TP53
Long gene name tumor protein p53
Synonyms p53 LFS1
Synonyms name Li-Fraumeni syndrome
Locus 17p13, 1
Discovery year 1986-01-01
GenBank acession AF307851
Entrez gene record 7157
Pubmed identfication 6396087 3456488 2047879
RefSeq identity NM_000546
Havana BLAST/BLAT OTTHUMG00000162125
Locus Specific Databases IARC TP53 Mutation Database p53 UMD TP53 mutation database Database of Germline p53 Mutations MUTP53LOAD, Mutant p53 Loss Of Activity Database LRG_321

Similar products

Subscribe to our Newsletter