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p57Kip2 Antibody

p57Kip2 Antibody size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenp57Kip2
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
Notes Titration of the p57Kip2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis p57Kip2 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P49919
PurityAntigen affinity
Description Diaz-Meyer et al, Matsuoka et al, Mutations of p57Kip2 are implicated in sporadic cancers and Beckwith-Wiedemann syndrome suggesting that it is a tumor suppressor candidate, The CDKN1C gene encodes a potent tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation, The gene contains 3 exons, The gene is paternally imprinted, a familial cancer syndrome, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, also called p57(KIP2) or KIP2, is a protein which in humans is encoded by the CDKN1C imprinted gene, making it a tumor suppressor candidate, with preferential expression of the maternal allele, (1995)demonstrated that the gene is located on chromosome 11p15, (2005) concluded that p57Kip2 may be downregulated by multiple mechanisms including some that do not involve promoter methylation, 5, Cyclin-dependent kinase inhibitor 1C
ImmunogenAn amino acid sequence from the N-terminus of mouse p57 Kip2 (RLAELNAEDQNRWDFNFQQD) was used as the immunogen for this p57Kip2 antibody (100% rat homology)
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the p57Kip2 antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetp57Kip2
Short namep57Kip2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namep57Kip2 (Antibody to)
Alternative techniqueantibodies

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