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p70 S6 kinase alpha Antibody

p70 S6 kinase alpha Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namep70 S6 kinase alpha Primary Polyclonal Antibody
Also known asp70 S6 kinase alpha PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target Antigenp70 S6 kinase alpha
Specificity This antibody may detect p70 ribosomal S6 kinase beta 2, This is a highly specific antibody against p70 S6 kinase alpha
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range280-330/525
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human p70 S6 kinase alpha
Gene ID number6198
Swiss ProtP23443
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Also controls translation initiation by phosphorylating a negative regulator of EIF4A, Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, In cells lacking functional TSC1-2 complex, In response to IGF1, Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function, PDCD4, Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex, Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR, RPS6 and EEF2K, Regulates protein synthesis through phosphorylation of EIF4B, The active form then phosphorylates and activates several substrates in the pre-initiation complex, The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, Under conditions of nutrient depletion, Upon mitogenic stimulation, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), and contributes to cell survival by repressing the pro-apoptotic function of BAD, cell growth and cell cycle progression, constitutively phosphorylates and inhibits GSK3B, including the EIF2B complex and the cap-binding complex component EIF4B, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation, resulting in accelerated degradation of IRS1, resulting in the inhibition of mTORC2 and AKT1 signaling, targeting it for ubiquitination and subsequent proteolysis, the inactive form associates with the EIF3 translation initiation complex, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function, which leads to its inhibition and thus activation of EEF2, Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 70 kDa ribosomal protein S6 kinase 1, P70S6K1, PS6K, RPS6KB1, Ribosomal protein S6 kinase I, Ribosomal protein S6 kinase beta-1, S6K-beta-1, S6K1, STK14A, Serine/threonine-protein kinase 14A, p70 S6 kinase alpha, p70 S6K-alpha, p70 S6KA, p70 ribosomal S6 kinase alpha, p70(S6K)-alpha, p70-S6K, p70-S6K 1, p70-alpha, S6K
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetp70 S6 kinase alpha
Short namep70 S6 kinase alpha Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namep70 S6 phosphorylation catalyst a (Antibody to)
Alternative techniqueantibodies

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