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Parkin/PARK2 Antibody

Parkin/PARK2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameParkin/PARK2 Primary Polyclonal Antibody
Also known asParkin/PARK2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPARK2
SpecificityThis is a highly specific antibody against PARK2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range390-440/465
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human E3 ubiquitin-protein ligase parkin
Gene ID number5071
Swiss ProtO60260
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen CCNE1, GPR37, GPR37 accumulation, In collaboration with CHPF isoform 2, Independently of its ubiquitin ligase activity, Limits the production of reactive oxygen species (ROS), MFN1, MFN2, May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis, May protect neurons against alpha synuclein toxicity, May represent a tumor suppressor gene, Mediates 'Lys-48'-linked polyubiquitination of ZNF746, Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context, Mediates monoubiquitination of BCL2, Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by the ubiquitination of mitochondrial proteins such as TOMM2, RHOT1/MIRO1, RHOT1/MIRO1 and USP3 (PubMed:24896179), Regulates cyclin-E during neuronal apoptosis, SEPT5, STUB1, SYT11, TOMM2, USP3, ZNF746 and AIMP2, a 22 kDa O-linked glycosylated isoform of SNCAIP, and kainate-induced excitotoxicity, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, followed by degradation, followed by degradation of ZNF746 by the proteasome, leading to their recruitment to aggresomes, may enhance cell viability and protect cells from oxidative stress, possibly playing a role in Lewy-body formation, possibly playing a role in the regulation of neuron death, proteasomal dysfunction, protects from apoptosis by the transcriptional repression of p53/TP53, such as BCL2, thereby acting as a positive regulator of autophagy, Functions within a multiprotein E3 ubiquitin ligase complex
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AR-JP, E3 ubiquitin-protein ligase parkin, LPRS2, PARK2, PRKN, Parkinson disease protein 2, Parkinson juvenile disease protein 2, PDJ
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetParkin/PARK2
Short nameParkin/PARK2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameParkin/PARK2 (Antibody to)
Alternative techniqueantibodies
Identity 8607
Gene PARK2
Long gene name parkin RBR E3 ubiquitin protein ligase
Synonyms gene name E3 ubiquitin protein ligase (parkin) , Parkinson disease (autosomal recessive, juvenile) 2, parkin parkinson protein 2
Synonyms PDJ AR-JP parkin PRKN
Synonyms name E3 ubiquitin ligase
Locus 6q26
Discovery year 1997-08-18
Entrez gene record 5071
Pubmed identfication 9560156 9570960
Classification Parkinson disease associated genes RBR E3 ubiquitin ligases
Havana BLAST/BLAT OTTHUMG00000015970
Locus Specific Databases Parkinson', s disease Mutation Database

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