Parkin/PARK2 Antibody, Biotin Conjugated

Parkin/PARK2 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1

Price 333

Size 0.1ml

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Long name	Biotin Conjugated, Parkin/PARK2 Polyclonal Antibody
Category	Conjugated Primary Antibodies
Conjugation	Biotinylated
Host Organism	Rabbit (Oryctolagus cuniculus)
Target Antigen	PARK2
Specificity	This is a highly specific antibody against PARK2
Modification	Unmodified
Modification site	None
Clonality	Polyclonal
Clone	Polyclonal antibody
Concentration	1ug per 1ul
Immunogen_range	390-440/465
Subcellular location	Nucleus, Cytoplasm
Source	KLH conjugated synthetic peptide derived from human E3 ubiquitin-protein ligase parkin
Gene ID number	5071
Swiss Prot	O60260
Tested applications	IHC-P, WB
Recommended dilutions	IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity	Mouse, Rat, Human
Crossreactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background	CCNE1, GPR37, GPR37 accumulation, In collaboration with CHPF isoform 2, Independently of its ubiquitin ligase activity, Limits the production of reactive oxygen species (ROS), MFN1, MFN2, May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis, May protect neurons against alpha synuclein toxicity, May represent a tumor suppressor gene, Mediates 'Lys-48'-linked polyubiquitination of ZNF746, Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context, Mediates monoubiquitination of BCL2, Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by the ubiquitination of mitochondrial proteins such as TOMM2, RHOT1/MIRO1, RHOT1/MIRO1 and USP3 (PubMed:24896179), Regulates cyclin-E during neuronal apoptosis, SEPT5, STUB1, SYT11, TOMM2, USP3, ZNF746 and AIMP2, a 22 kDa O-linked glycosylated isoform of SNCAIP, and kainate-induced excitotoxicity, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, followed by degradation, followed by degradation of ZNF746 by the proteasome, leading to their recruitment to aggresomes, may enhance cell viability and protect cells from oxidative stress, possibly playing a role in Lewy-body formation, possibly playing a role in the regulation of neuron death, proteasomal dysfunction, protects from apoptosis by the transcriptional repression of p53/TP53, such as BCL2, thereby acting as a positive regulator of autophagy, Functions within a multiprotein E3 ubiquitin ligase complex
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission	N/A
Synonyms	PDJ AR-JP parkin PRKN
Properties	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target	Parkin/PARK2 Conjugated
Short name	Conjugated, Parkin/PARK2 Antibody
Technique	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label	Biotin
Alternative name	biotinilated coupled, Parkin/PARK2 (Antibody to)
Alternative technique	antibodies
Identity	8607
Gene	PARK2
Long gene name	parkin RBR E3 ubiquitin protein ligase
Synonyms gene name	E3 ubiquitin protein ligase (parkin) , Parkinson disease (autosomal recessive, juvenile) 2, parkin parkinson protein 2
Synonyms name	E3 ubiquitin ligase
Locus	6q26
Discovery year	1997-08-18
Entrez gene record	5071
Pubmed identfication	9560156 9570960
Classification	Parkinson disease associated genes RBR E3 ubiquitin ligases
Havana BLAST/BLAT	OTTHUMG00000015970
Locus Specific Databases	Parkinson', s disease Mutation Database

Parkin/PARK2 Antibody, Biotin Conjugated

Parkin/PARK2 Antibody, Biotin Conjugated size: 0.1ml 333

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