| Long name | PARP1 Primary Polyclonal Antibody |
| Also known as | PARP1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | PARP1 |
| Specificity | This is a highly specific antibody against PARP1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 200-230/1014 |
| Subcellular location | Nucleus |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PARP1 |
| Gene ID number | 142 |
| Swiss Prot | P09874 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Mediates the poly(ADP-ribosyl)ation of APLF and CHFR, PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150, Required for PARP9 and DTX3L recruitment to DNA damage sites, This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks, UIMC1/RAP80, With EEF1A1 and TXK, and BRCA1 to DNA damage sites, and is thus involved importantly in Th1 cytokine production, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, Involved in the base excision repair (BER) pathway |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | ADP-ribosyltransferase diphtheria toxin-like 1, ADPRT, ADPRT 1, ADPRT1, ARTD1, NAD(+) ADP-ribosyltransferase 1, PARP-1, PARP1, PPOL, Poly [ADP-ribose] polymerase 1, Poly[ADP-ribose] synthase 1, pADPRT-1, PARP |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | PARP1 |
| Short name | PARP1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | PARP1 (Antibody to) |
| Alternative technique | antibodies |
| Identity | 270 |
| Gene | PARP1 |
| Long gene name | poly(ADP-ribose) polymerase 1 |
| Synonyms gene | PPOL ADPRT |
| Synonyms gene name | ADP-ribosyltransferase (NAD+, member 1 , poly (ADP-ribose) polymerase) poly (ADP-ribose) polymerase family |
| Synonyms | PARP |
| Locus | 1q42, 12 |
| Discovery year | 1986-01-01 |
| GenBank acession | BC037545 |
| Entrez gene record | 142 |
| Pubmed identfication | 10964595 |
| RefSeq identity | NM_001618 |
| Classification | Zinc fingers PARP-type Zinc fingers Poly(ADP-ribose) polymerases |
| Havana BLAST/BLAT | OTTHUMG00000037556 |
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