| Long name | PAX4 Primary Polyclonal Antibody |
| Also known as | PAX4 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | PAX4 |
| Specificity | This is a highly specific antibody against PAX4 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PAX4 |
| Gene ID number | 5078 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Classical features are polydipsia, Competes with PAX6 for this same promoter binding site, Defects in PAX4 are a cause of noninsulin-dependent diabetes mellitus (NIDDM) , IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas, Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity, KPD is an atypical form of diabetes mellitus characterized by an acute initial presentation with severe hyperglycemia and ketosis, Metabolic studies show a markedly blunted insulin secretory response to glucose, NIDDM is characterized by an autosomal dominant mode of inheritance, Pancreatic beta-cell autoimmunity is a rare finding, Transcriptional repressor that binds to a common element in the glucagon, Variable levels of insulin resistance are observed, also known as diabetes mellitus type 2 or maturity-onset diabetes, as seen in classic type 1 diabetes, but after initiation of insulin therapy, due to hyperglycemia-induced osmotic diuresis, especially in obese patients, insulin and somatostatin promoters, onset during adulthood and insulin resistance, partially reversible with the improvement of blood glucose control, polyphagia and polyuria, prolonged remission is often possible with cessation of insulin therapy and maintenance of appropriate metabolic control, Defects in PAX4 are a cause of susceptibility to diabetes mellitus ketosis-prone (KPD), Genetic variations in PAX4 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM), Involvement in disease, Plays an important role in the differentiation and development of pancreatic islet beta cells |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | MODY9, PAX4_HUMAN, Paired box 4, Paired box gene 4, Paired box protein Pax-4, Paired domain gene 4, Pax4, paired box homeotic gene 4, KPD |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | PAX4 |
| Short name | PAX4 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | paired box 4 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007623 and circadian rhythm and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0030154 and cell differentiation and biological process this GO :0031018 and endocrine pancreas development and biological process this GO :0042493 and response to drug and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045595 and regulation of cell differentiation and biological process this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0051591 and response to cAMP and biological process this GO :0060041 and retina development in camera-type eye and biological process, KPD and MODY9, PAX4 and IDBG-39446 and ENSG00000106331 and 5078, PAX4 and IDBG-634967 and ENSBTAG00000000410 and 526172, Pax4 and IDBG-130592 and ENSMUSG00000029706 and 18506, nuclei, sequence-specific DNA binding, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000980 and RNA polymerase II distal enhancer sequence-specific DNA binding and molecular function this GO :0001206 and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0006351 and transcription, this GO :0000980: RNA polymerase II distal enhancer sequence-specific DNA binding, this GO :0000980: RNA polymerase II distal enhancer sequence-specific DNA binding and also this GO :0001206: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and also this GO :0003677: DNA binding and also this GO :0003690: double-stranded DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0043565: sequence-specific DNA binding, this GO :0001206: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription, this GO :0003677: DNA binding, this GO :0003690: double-stranded DNA binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0043565: sequence-specific DNA binding, paired box 4 |
| Identity | 8618 |
| Gene | PAX4 |
| Long gene name | paired box 4 |
| Synonyms gene name | paired box gene 4 |
| Synonyms | MODY9 |
| Locus | 7q32, 1 |
| Discovery year | 1993-04-07 |
| Entrez gene record | 5078 |
| Classification | PRD class homeoboxes and pseudogenes Paired boxes |
| Havana BLAST/BLAT | OTTHUMG00000157562 |
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