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PCNA(1C11) Monoclonal Antibody

PCNA(1C11) Monoclonal Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePCNA(1C11) Monoclonal Antibody
Also known asPCNA(1C11) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPCNA
SpecificityThis is a highly specific antibody against PCNA
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1C11
Concentration1ug per 1ul
Immunogen range200-250/261
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PCNA
Gene ID number5111
Swiss ProtP12004
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Rabbit, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen APEX2 activities, Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, Has to be loaded onto DNA in order to be able to stimulate APEX2, Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways, but not apurinic-apyrimidinic (AP) endonuclease, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion, Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Cyclin, PCNA, Proliferating cell nuclear antigen, ATLD2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetPCNA(1C11) Monoclonal
Short namePCNA(1C11) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative namePCNA(1C11) monoclonal (Antibody to)
Alternative techniqueantibodies
Identity 8729
Gene PCNA
Long gene name proliferating cell nuclear antigen
Locus 20p12, 3
Discovery year 1990-01-15
GenBank acession J04718
Entrez gene record 5111
Pubmed identfication 2565339
Havana BLAST/BLAT OTTHUMG00000031798

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