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PCNA-Proliferation Marker Antibody

PCNA-Proliferation Marker Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePCNA-Proliferation Marker Antibody
Also known asPCNA-Proliferation Marker Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPCNA-proliferation Marker
SpecificityThis is a highly specific antibody against PCNA-proliferation Marker
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range209-241/261
Subcellular location Helical, Nucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PCNA
Gene ID number5111
Swiss ProtP12004
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen APEX2 activities, Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, Has to be loaded onto DNA in order to be able to stimulate APEX2, Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways, but not apurinic-apyrimidinic (AP) endonuclease, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion, Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Cyclin, PCNA, Proliferating cell nuclear antigen, ATLD2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetPCNA-Proliferation
Short namePCNA-Proliferation Marker Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePCNA-expantion detection labelled (Antibody to)
Alternative techniqueantibodies
Identity 8729
Gene PCNA
Long gene name proliferating cell nuclear antigen
Locus 20p12, 3
Discovery year 1990-01-15
GenBank acession J04718
Entrez gene record 5111
Pubmed identfication 2565339
Havana BLAST/BLAT OTTHUMG00000031798

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