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PD-L1 Antibody

PD-L1 Antibody size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenPD-L1
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
Notes Titration of the PD-L1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting points
Intented useThis PD-L1 antibodyis to be used only for research purposes and not for diagnostics
Gene ID #29126
PurityAntigen affinity
Description It can provide positive costimulatory signals for innate and adaptive immunity and for protection against intracellular bacterial infection, It has been found that PD1/PDL1 pathway may be a good target for restoring antitumor immunity in ovarian cancer, It is a 33-70kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, Upregulation on tumor MDCs downregulates T-cell immunity and PD-L1 blockade may represent an approach for cancer immunotherapy, also known as CD274 or B7-H1 is a protein that in humans is encoded by the CD274 gene, autoimmune disease and other disease states such as hepatitis, tissue allografts, Programmed death-ligand 1
ImmunogenHuman partial recombinant protein (AA 45-290) was used as the immunogen for this PD-L1 antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the PD-L1 antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetPD-L1
Short namePD-L1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePD-L1 (Antibody to)
Alternative techniqueantibodies
Identity 17635
Gene CD274
Long gene name CD274 molecule
Synonyms gene PDCD1LG1
Synonyms gene name programmed cell death 1 ligand 1 CD274 antigen
Synonyms B7-H B7H1 PD-L1 PDL1 B7-H1
Synonyms name B7 homolog 1
Locus 9p24, 1
Discovery year 2003-11-13
GenBank acession AF177937
Entrez gene record 29126
Pubmed identfication 11015443 10581077
RefSeq identity NM_014143
Classification Endogenous ligands C2-set domain containing CD molecules V-set domain containing
Havana BLAST/BLAT OTTHUMG00000019503

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