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PDK4 (345CT19.6.2) Monoclonal Antibody

PDK4 (345CT19.6.2) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name2) Monoclonal Antibody, 6, PDK4 (345CT19
Also known as2) Monoclonal Antibody, 6, PDK4 (345CT19
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPDK4
SpecificityThis is a highly specific antibody against PDK4
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number2, 345CT19, 6
SourcePurified His-tagged PDK4 protein(Fragment) was used to produced this monoclonal antibody
Gene ID number5166
Swiss ProtQ16654
Tested ApplicationsWB
Recommended dilutionsWB(1:100-1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen In the fed state, Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation, Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism, Plays a role in the generation of reactive oxygen species, Plays an important role in maintaining normal blood glucose levels under starvation, Protects detached epithelial cells against anoikis, Regulates both fatty acid oxidation and de novo fatty acid biosynthesis, This inhibits pyruvate dehydrogenase activity, Via its regulation of pyruvate dehydrogenase activity, and is involved in the insulin signaling cascade, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate, mediates cellular responses to glucose levels and to a high-fat diet, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation, Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2
Purification method This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names PDHK4, PDK4, Pyruvate dehydrogenase kinase isoform 4, mitochondrial, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target2) Monoclonal, 6, PDK4 (345CT19
Short name2) Monoclonal Antibody, 6, PDK4 (345CT19
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name2) monoclonal (Antibody to), 6, PDK4 (345CT19
Alternative techniqueantibodies
Identity 8812
Gene PDK4
Long gene name pyruvate dehydrogenase kinase 4
Synonyms gene name isoenzyme 4 pyruvate dehydrogenase kinase, isozyme 4 , pyruvate dehydrogenase kinase
Locus 7q21, 3
Discovery year 1996-08-14
GenBank acession U54617
Entrez gene record 5166
Pubmed identfication 7499431
RefSeq identity NM_002612
Havana BLAST/BLAT OTTHUMG00000153977

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