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Phospho-ErbB2 Antibody (pY1221)

Phospho-ErbB2 Antibody (pY1221) size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenPhospho-ErbB2 (pY1221)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, WB
Recommended dilutionsWestern blot: 1:2000-4000
NotesTitration of the phospho-ErbB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis phospho-ErbB2 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P04626
PurityAntigen affinity
Description Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription, Essential component of a neuregulin-receptor complex, GP30 is a potential ligand for this receptor, Implicated in transcriptional activation of CDKN1A, In the nucleus is involved in transcriptional regulation, In turn, Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth, Regulates outgrowth and stabilization of peripheral microtubules (MTs), This prevents the phosphorylation of APC and CLASP2, Upon ERBB2 activation, allowing its association with the cell membrane, although neuregulins do not interact with it alone, but that apparently needs a coreceptor for ligand binding, membrane-bound APC allows the localization of MACF1 to the cell membrane, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane, the function involves STAT3 and SRC, which is required for microtubule capture and stabilization, Protein tyrosine kinase that is part of several cell surface receptor complexes
ImmunogenThis phospho-ErbB2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY1221 of human ErbB2
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the phospho-ErbB2 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetPhospho-ErbB2 (pY1221)
Short namePhospho-ErbB2 Antibody (pY1221)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name neuro/glioblastoma derived oncogene homolog (avian) (Antibody to) (pY1221), phosphorilated-v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
Alternative techniqueantibodies

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