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Phospho-IKKB Antibody (pS689)

Phospho-IKKB Antibody (pS689) size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenPhospho-IKKB (pS689)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, DB
Recommended dilutionsDot blot: 1:500
NotesTitration of the phospho-IKKB antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis phospho-IKKB antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O14920
PurityAntigen affinity
Description Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, R is an A or G purine, RELA, The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), and Y is a C or T pyrimidine), or RELB to form the NFKB complex, or T, thereby allowing activation of the NF-kappa-B complex, which inactivate NF-kappa-B by trapping it in the cytoplasm, NFKB1 or NFKB2 is bound to REL
ImmunogenThis phospho-IKKB antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS689 of human IKKB
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the phospho-IKKB antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetPhospho-IKKB (pS689)
Short namePhospho-IKKB Antibody (pS689)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namephosphorilated-IKKB (Antibody to) (pS689)
Alternative techniqueantibodies
Identity 5960
Gene IKBKB
Long gene name inhibitor of nuclear factor kappa B kinase subunit beta
Synonyms gene name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Synonyms IKK2 NFKBIKB IKK-beta IKKB
Locus 8p11, 21
Discovery year 1998-02-11
GenBank acession AF029684
Entrez gene record 3551
Pubmed identfication 9878263 9763654 18308615
Havana BLAST/BLAT OTTHUMG00000164092

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