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PI3 Kinase p110 beta(Ser1070) Antibody, ALEXA FLUOR 594

PI3 Kinase p110 beta(Ser1070) Antibody, ALEXA FLUOR 594 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 594 Conjugated, PI3 Kinase p110 beta(Ser1070) Antibody
Also known asAnti-PI3 Kinase p110 beta Ser1070 PAb ALEXA FLUOR 594
CategoryConjugated Primary Antibodies
Conjugated with 594, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenPI3 Kinase p110 beta Ser1070
SpecificityThis is a highly specific antibody against PI3 Kinase p110 beta Ser1070
ModificationPhosphorylation
Modification SiteSer1070
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range1020-1070/1070
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human PI3 Kinase p110 beta around the phosphorylation site of Ser1070
Gene ID Number5291
Swiss ProtP42338
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Has a role in cell survival, Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, Involved in the early stage of autophagosome formation, May act as a scaffold, May also act downstream receptor tyrosine kinases, May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis, May have a role in cell migration, May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required, Mediator of oncogenic signal in cell lines lacking PTEN, Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity, PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, Plays a role in platelet activation signaling triggered by GPCRs, PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4, Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces, Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2), Required for the growth of ERBB2 and RAS driven tumors, Required in different signaling pathways for stable platelet adhesion and aggregation, The lipid kinase activity is necessary for its role in oncogenic transformation, activating signaling cascades involved in cell growth, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6, and lysophosphatidic acid, including AKT1 and PDPK1, independently of its lipid kinase activity to positively regulate autophagy, motility and morphology, proliferation, sphingosine 1-phosphate, survival, 4, 5)P2 (Phosphatidylinositol 4, 5-bisphosphate) to generate phosphatidylinositol 3, 5-trisphosphate (PIP3), Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol)
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission590nm/617nm
Synonyms ESI SKALP ELAFIN WAP3 WFDC14 cementoin
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation 594, ALEXA FLUOR®, Alexa Fluor
ConjugatedAlexa conjugate 1
Gene targetPI3 Kinase p110 beta(Ser1070)
Short namePI3 Kinase p110 beta(Ser1070) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 594
Alternative name ALEXA FLUOR 594, PI3 phosphorylation catalyst p110 b(Ser1070) (Antibody to)
Alternative techniqueantibodies
Identity 8947
Gene PI3
Long gene name peptidase inhibitor 3
Synonyms gene name protease inhibitor 3, skin-derived , skin-derived (SKALP) peptidase inhibitor 3
Synonyms name skin-derived antileukoproteinase trappin-2
Locus 20q13, 12
Discovery year 1993-07-27
GenBank acession D13156
Entrez gene record 5266
Pubmed identfication 8287685 12206714
RefSeq identity NM_002638
Classification WAP four-disulfide core domain containing
Havana BLAST/BLAT OTTHUMG00000032567

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