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PIN1 (855CT1.7.5) Monoclonal Antibody

PIN1 (855CT1.7.5) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name5) Monoclonal Antibody, 7, PIN1 (855CT1
Also known as5) Monoclonal Antibody, 7, PIN1 (855CT1
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPIN1
SpecificityThis is a highly specific antibody against PIN1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number5, 7, 855CT1
SourcePurified His-tagged PIN1 protein was used to produced this monoclonal antibody
Gene ID number5300
Swiss ProtQ13526
Tested Applications FCM, IHC-P, WB
Recommended dilutions IHC-P(1:25), IHC-P(1:25)
Cross reactivity Mouse, Other Species, Rat, Human
Cross reactive species detailsAfrican Green Monkey
Background of the target antigen Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269), Can transactivate multiple oncogenes and induce centrosome amplification, Displays a preference for an acidic residue N-terminal to the isomerized proline bond, Down-regulates kinase activity of BTK (PubMed:16644721), PubMed:22033920), Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity, Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191), chromosome instability and cell transformation, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923), resulting in conformational changes in the proteins (PubMed:21497122, Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins
Purification method This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names PIN1, PPIase Pin1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase Pin1, Rotamase Pin1, UBL5, DOD
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target5) Monoclonal, 7, PIN1 (855CT1
Short name5) Monoclonal Antibody, 7, PIN1 (855CT1
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name NIMA-interacting 1 (855CT1, 5) monoclonal (Antibody to), 7, peptidylprolyl cis/trans isomerase
Alternative techniqueantibodies
Alternative to gene target DOD and UBL5, NIMA-interacting 1, PIN1 and IDBG-26087 and ENSG00000127445 and 5300, PIN1 and IDBG-643081 and ENSBTAG00000016988 and 535470, nuclei, phosphothreonine binding, this GO :0000413 and protein peptidyl-prolyl isomerization and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0003755 and peptidyl-prolyl cis-trans isomerase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006457 and protein folding and biological process this GO :0007049 and cell cycle and biological process this GO :0007088 and regulation of mitosis and biological process this GO :0016607 and nuclear speck and cellular component this GO :0016853 and isomerase activity and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030496 and midbody and cellular component this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0031434 and mitogen-activated protein kinase kinase binding and molecular function this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0032465 and regulation of cytokinesis and biological process this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0032794 and GTPase activating protein binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0050815 and phosphoserine binding and molecular function this GO :0050816 and phosphothreonine binding and molecular function this GO :0051443 and positive regulation of ubiquitin-protein transferase activity and biological process this GO :0060393 and regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0070373 and negative regulation of ERK1 and ERK2 cascade and biological process this GO :2000146 and negative regulation of cell motility and biological process, this GO :0003755: peptidyl-prolyl cis-trans isomerase activity, this GO :0003755: peptidyl-prolyl cis-trans isomerase activity and also this GO :0005515: protein binding and also this GO :0016853: isomerase activity and also this GO :0031434: mitogen-activated protein kinase kinase binding and also this GO :0032794: GTPase activating protein binding and also this GO :0050815: phosphoserine binding and also this GO :0050816: phosphothreonine binding, this GO :0005515: protein binding, this GO :0016853: isomerase activity, this GO :0031434: mitogen-activated protein kinase kinase binding, this GO :0032794: GTPase activating protein binding, this GO :0050815: phosphoserine binding, this GO :0050816: phosphothreonine binding, peptidylprolyl cis/trans isomerase
Identity 8988
Gene PIN1
Long gene name NIMA-interacting 1 , peptidylprolyl cis/trans isomerase
Synonyms gene name protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
Synonyms dod
Locus 19p13
Discovery year 1996-12-16
Entrez gene record 5300
Pubmed identfication 8606777
Classification Parvulins
Havana BLAST/BLAT OTTHUMG00000180388
Locus Specific Databases LRG_847

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