Filters

PINK1 (38CT20.8.5) Monoclonal Antibody

PINK1 (38CT20.8.5) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name5) Monoclonal Antibody, 8, PINK1 (38CT20
Also known as5) Monoclonal Antibody, 8, PINK1 (38CT20
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPINK1
SpecificityThis is a highly specific antibody against PINK1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number38CT20, 5, 8
SourceRecombinant PINK1 protein was used to produced this monoclonal antibody
Gene ID number65018
Swiss ProtQ9BXM7
Tested Applications IF, IHC-P, WB
Recommended dilutions IHC-P(1:25), WB(1:2000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2, PubMed:24751536, PubMed:24784582, PubMed:25527291), Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2, converting PARK2 to its fully-active form (PubMed:24660806, Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins
Purification method This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names PARK6, PINK1, PTEN-induced putative kinase protein 1, Serine/threonine-protein kinase PINK1, mitochondrial, BRPK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target5) Monoclonal, 8, PINK1 (38CT20
Short name5) Monoclonal Antibody, 8, PINK1 (38CT20
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name5) monoclonal (Antibody to), 8, phosphatase and tensin homolog induced putative kinase 1 (38CT20
Alternative techniqueantibodies
Alternative to gene target PINK1 and IDBG-645657 and ENSBTAG00000006084 and 510683, PINK1 and IDBG-92922 and ENSG00000158828 and 65018, Pink1 and IDBG-199773 and ENSMUSG00000028756 and 68943, dopaminergic and biological process this GO :0033603 and positive regulation of dopamine secretion and biological process this GO :0033605 and positive regulation of catecholamine secretion and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043254 and regulation of protein complex assembly and biological process this GO :0043523 and regulation of neuron apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0055131 and C3HC4-type RING finger domain binding and molecular function this GO :0090200 and positive regulation of release of cytochrome c from mitochondria and biological process this GO :0097237 and cellular response to toxic substance and biological process this GO :1902176 and negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and biological process, nuclei, this GO :0000287 and magnesium ion binding and molecular function this GO :0000422 and mitochondrion degradation and biological process this GO :0000785 and chromatin and cellular component this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005758 and mitochondrial intermembrane space and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006950 and response to stress and biological process this GO :0008219 and cell death and biological process this GO :0010857 and calcium-dependent protein kinase activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016567 and protein ubiquitination and biological process this GO :0016772 and transferase activity, this GO :0000287: magnesium ion binding, this GO :0000287: magnesium ion binding and also this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0010857: calcium-dependent protein kinase activity and also this GO :0016301: kinase activity and also this GO :0016772: transferase activity, this GO :0004672: protein kinase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0010857: calcium-dependent protein kinase activity, this GO :0016301: kinase activity, this GO :0016772: transferase activity, this GO :0031625: ubiquitin protein ligase binding, this GO :0055131: C3HC4-type RING finger domain binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0031625: ubiquitin protein ligase binding and also this GO :0055131: C3HC4-type RING finger domain binding, transferring phosphorus-containing groups and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0031396 and regulation of protein ubiquitination and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032226 and positive regulation of synaptic transmission, PTEN induced putative kinase 1
Identity 14581
Gene PINK1
Long gene name PTEN induced putative kinase 1
Synonyms gene PARK6
Synonyms gene name Parkinson disease (autosomal recessive) 6
Locus 1p36, 12
Discovery year 2001-02-08
GenBank acession AB053323
Entrez gene record 65018
Pubmed identfication 11494141 15349860
RefSeq identity NM_032409
Classification Parkinson disease associated genes
Havana BLAST/BLAT OTTHUMG00000002841
Locus Specific Databases Parkinson', s disease Mutation Database

Similar products

Subscribe to our Newsletter