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PKMYT1(Thr495) Antibody, ALEXA FLUOR 555

PKMYT1(Thr495) Antibody, ALEXA FLUOR 555 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, PKMYT1(Thr495) Polyclonal Antibody
Also known asAnti-PKMYT1 Thr495 PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenPKMYT1 Thr495
SpecificityThis is a highly specific antibody against PKMYT1 Thr495
ModificationPhosphorylation
Modification SiteThr495
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human PKMYT1 around the phosphorylation site of Thr495
Gene ID Number2475
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
CrossreactivityHuman
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis, Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2), In parallel to protein synthesis, MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins, Moreover, Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor, Stimulates the pyrimidine biosynthesis pathway, This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E), To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A, Under nutrient sufficiency, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1, an allosteric activator of CAD at a later step in synthesis, and delayed regulation, and the inhibitor of translation initiation PDCD4, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, disrupting the interaction with AMPK and preventing activation of ULK1, energy and stress signals, eukaryotic translation initiation factor EIF4B, growth and survival in response to hormones, growth factors, mTORC1 also negatively regulates autophagy through phosphorylation of ULK1, nutrients, phosphorylates ULK1 at 'Ser-758', phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, this function is dependent on the mTORC1 complex, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), Serine/threonine protein kinase which is a central regulator of cellular metabolism
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Synonyms MYT1 PPP1R126
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetPKMYT1(Thr495)
Short namePKMYT1(Thr495) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, PKMYT1(Thr495) (Antibody to)
Alternative techniqueantibodies
Identity 29650
Gene PKMYT1
Long gene name membrane associated tyrosine/threonine 1 , protein kinase
Synonyms name membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase protein phosphatase 1, regulatory subunit 126
Locus 16p13, 3
Discovery year 2005-01-20
GenBank acession AK097642
Entrez gene record 9088
Pubmed identfication 9001210 12606722
RefSeq identity NM_004203
Classification Protein phosphatase 1 regulatory subunits
Havana BLAST/BLAT OTTHUMG00000128975

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