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PLK1 (Ser137) Antibody

PLK1 (Ser137) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePLK1 (Ser137) Primary Polyclonal Antibody
Also known asPLK1 (Ser137) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPLK1 Ser137
Specificity This phosphorylation site is homologous across the listed species, This is a highly specific antibody against PLK1 Ser137
Modification(s)Phosphorylation
Modification site(s)Ser137
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range110-160/603
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human PLK1 around the phosphorylation site of Ser137
Gene ID number5347
Swiss ProtP53350
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Contributes to the regulation of AURKA function, NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, Phosphorylates BORA, Phosphorylates NEDD1, Phosphorylates SGOL1, Phosphorylates both ECT2 and RACGAP1, Promotes the central spindle recruitment of ECT2, Regulates TP53 stability through phosphorylation of TOPORS, Required for kinetochore localization of BUB1B, Required for recovery after DNA damage checkpoint and entry into mitosis, Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function, an important step for spindle formation, and the regulation of mitotic exit and cytokinesis, and thereby promotes the degradation of BORA, and thereby stimulates their interaction that is essential for the cleavage furrow formation, including the regulation of centrosome maturation and spindle assembly, the inactivation of APC/C inhibitors, the removal of cohesins from chromosome arms, Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names PLK-1, PLK1, Polo-like kinase 1, STPK13, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase PLK1, PLK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetPLK1 (Ser137)
Short namePLK1 (Ser137) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePLK1 (Ser137) (Antibody to)
Alternative techniqueantibodies
Identity 9077
Gene PLK1
Long gene name polo like kinase 1
Synonyms gene PLK
Synonyms gene name polo-like kinase (Drosophila) polo-like kinase 1
Locus 16p12, 2
Discovery year 1994-07-25
Entrez gene record 5347
Pubmed identfication 8127874
RefSeq identity NM_005030
Havana BLAST/BLAT OTTHUMG00000096984

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