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PNPT1 Antibody

PNPT1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePNPT1 Primary Polyclonal Antibody
Also known asPNPT1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPNPT1
SpecificityThis is a highly specific antibody against PNPT1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range570-620/783
Subcellular location Mitochondrion, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PNPT1
Gene ID number87178
Swiss ProtQ8TCS8
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Binds to the RNA subunit of ribonuclease P, Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction, Component of the mitochondrial degradosome (mtEXO) complex, In the cytoplasm, MRP RNA and miR-221 microRNA, Mitochondrial intermembrane factor with RNA-processing exoribonulease activity, Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, Plays a role in mitochondrial morphogenesis and respiration, Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs, Regulates the stability of specific mature miRNAs in melanoma cells, Required for correct processing and polyadenylation of mitochondrial mRNAs, degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, into the mitochondrial matrix, like the 5S RNA, preferentially, regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels, resulting in a growth arrest in melanoma cells, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity, specifically and selectively degrades miR-221, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, RNA-binding protein implicated in numerous RNA metabolic processes
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 3'-5' RNA exonuclease OLD35, COXPD13, DFNB70, PNPASE, PNPT1, PNPase 1, PNPase old-35, Polynucleotide phosphorylase 1, Polynucleotide phosphorylase-like protein, Polyribonucleotide nucleotidyltransferase 1, mitochondrial, old-35, OLD35
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetPNPT1
Short namePNPT1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePNPT1 (Antibody to)
Alternative techniqueantibodies
Identity 23166
Gene PNPT1
Long gene name polyribonucleotide nucleotidyltransferase 1
Synonyms gene DFNB70
Synonyms gene name autosomal recessive 70 , deafness
Synonyms PNPase OLD35 old-35
Synonyms name RNA exonuclease , polynucleotide phosphorylase 3', -5'
Locus 2p16, 1
Discovery year 2003-09-25
GenBank acession BC053660
Entrez gene record 87178
Pubmed identfication 12419256
RefSeq identity NM_033109
Classification Deafness associated genes
Havana BLAST/BLAT OTTHUMG00000129335

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