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Polycystin 2 Antibody

Polycystin 2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePolycystin 2 Primary Polyclonal Antibody
Also known asPolycystin 2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPolycystin 2
Specificity This antibody may have a minor secondary cross-reactivity towards Polycystin 2-like protein 1 due to a 71% non-contiguous sequence similarity in the immunogen sequence, This is a highly specific antibody against Polycystin 2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range680-720/968
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Polycystin 2
Gene ID number5311
Swiss ProtQ13563
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a regulator of cilium length, Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity), PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis, The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling, Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040), leads to cilium shortening and thus decreases flow-induced signaling, together with PKD1, which decreases intracellular cAMP, Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names APKD2, Autosomal dominant polycystic kidney disease type II protein, PKD2, PKD4, Pc-2, Polycystic kidney disease 2 protein, Polycystin-2, Polycystwin, R48321, TRPP2, Transient receptor potential cation channel subfamily P member 2, PC2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetPolycystin 2
Short namePolycystin 2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePolycystin 2 (Antibody to)
Alternative techniqueantibodies
Identity 21715
Gene PKD1L2
Long gene name polycystin 1 like 2 (gene/pseudogene)
Synonyms gene name polycystic kidney disease 1-like 2
Synonyms KIAA1879
Locus 16q23, 2
Discovery year 2003-08-05
GenBank acession AY164483
Entrez gene record 114780
Pubmed identfication 12782129
Classification C-type lectin domain containing
Havana BLAST/BLAT OTTHUMG00000166126

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