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Polycystin 2 Antibody, Biotin Conjugated

Polycystin 2 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, Polycystin 2 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenPolycystin 2
Specificity This antibody may have a minor secondary cross-reactivity towards Polycystin 2-like protein 1 due to a 71% non-contiguous sequence similarity in the immunogen sequence, This is a highly specific antibody against Polycystin 2
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range680-720/968
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from human Polycystin 2
Gene ID number5311
Swiss ProtQ13563
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts as a regulator of cilium length, Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity), PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis, The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling, Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040), leads to cilium shortening and thus decreases flow-induced signaling, together with PKD1, which decreases intracellular cAMP, Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms APKD2, Autosomal dominant polycystic kidney disease type II protein, PKD2, PKD4, Pc-2, Polycystic kidney disease 2 protein, Polycystin-2, Polycystwin, R48321, TRPP2, Transient receptor potential cation channel subfamily P member 2, PC2
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetPolycystin 2 Conjugated
Short name Conjugated, Polycystin 2 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, Polycystin 2 (Antibody to)
Alternative techniqueantibodies

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