| Long name | Recombinant Pongo abelii CASP8 and FADD-like apoptosis regulator (CFLAR) |
| Alternative names | CASP8 and FADD-like apoptosis regulator, CASP8 and FADD-like apoptosis regulator, CASP8 and FADD-like apoptosis regulator |
| Gene name | CFLAR |
| Other gene names | CFLAR, CFLAR |
| General description | All of our recombinant proteins are manufactured in strictly controlled facilities and by using a well established technology which guarantees full batch-to-bact consistency and experiment reproducibility, The protein can be with or without a His-Tag or other tag in accordance to customer's request, CASP8 and FADD-like apoptosis regulator(CFLAR) is a recombinant protein expressed in Baculovirus |
| Product category | Recombinant Proteins |
| Expression system | Baculovirus |
| Available also expressed in: | Baculovirus , Mammalian Cell, Yeast , E Coli |
| Purity | Greater than 90% (determined by SDS-PAGE) |
| Form | Lyophilized protein |
| Storage | Avoid cycles of freezing and thawing as they might denaturate the polypeptide chains, For extended periods of time it is recommended to keep the protein frozen at -40 or -80 degrees Celsius, This protein can be stored at -20 degrees Celsius |
| Applications | IFA, RIA, Western Blot, etc, This protein can be used as a positive control for applications such as ELISA |
| Description | This 1 is suited for programmed cell-death studies |
| Gene target | Pongo abelii CASP8 FADD-like regulator (CFLAR) |
| Short name | Pongo abelii CASP8 FADD-like apoptosis regulator (CFLAR) |
| Technique | apoptosis pathway, apoptosis |
| Alternative name | apoptosis-related cysteine peptidase and Fas (TNF receptor superfamily, member 6) (TNFRSF6)-associated via death domain-like apoptosis regulator), member 6) (TNFRSF6)-associated via death domain-like programmed cellular destruction regulator (CASP8 and Fas (TNF receptor superfamily, Pongo abelii caspase 8 |
| Alternative technique | celldeath |
| Alternative to gene target | ALPS2B and CAP4 and Casp-8 and FLICE and MACH and MCH5, CASP8 and FADD-like apoptosis regulator, CASP8 and IDBG-643207 and ENSBTAG00000015718 and 507481, CASP8 and IDBG-78534 and ENSG00000064012 and 841, CFLAR and IDBG-78386 and ENSG00000003402 and 8837, Casp8 and IDBG-157464 and ENSMUSG00000026029 and 12370, FADD and IDBG-62144 and ENSG00000168040 and 8772, FADD and IDBG-645056 and ENSBTAG00000018274 and 493720, FLIP and IDBG-643202 and ENSBTAG00000010998 and 497199, Fadd and IDBG-212910 and ENSMUSG00000031077 and 14082, MORT1, Plasma membranes, Plasma membranes, alpha-beta cytotoxic T cell extravasation and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, apoptosis-related cysteine peptidase, c-FLIP and c-FLIPL and c-FLIPR and c-FLIPS and CASH and CASP8AP1 and Casper and CLARP and FLAME and FLAME-1 and FLAME1 and FLIP and I-FLICE and MRIT, caspase 8, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, death effector domain binding, identical protein binding, leucine rich repeat containing receptor signaling pathway and biological process this GO :0035877 and death effector domain binding and molecular function this GO :0036462 and TRAIL-activated apoptotic signaling pathway and biological process this GO :0042110 and T cell activation and biological process this GO :0042113 and B cell activation and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043005 and neuron projection and cellular component this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043124 and negative regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0044297 and cell body and cellular component this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045471 and response to ethanol and biological process this GO :0045651 and positive regulation of macrophage differentiation and biological process this GO :0045862 and positive regulation of proteolysis and biological process this GO :0046677 and response to antibiotic and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051603 and proteolysis involved in cellular protein catabolic process and biological process this GO :0060546 and negative regulation of necroptotic process and biological process this GO :0060715 and syncytiotrophoblast cell differentiation involved in labyrinthine layer development and biological process this GO :0070243 and regulation of thymocyte apoptotic process and biological process this GO :0070423 and nucleotide-binding oli this GO merization domain containing signaling pathway and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071407 and cellular response to organic cyclic compound and biological process this GO :0097110 and scaffold protein binding and molecular function this GO :0097153 and cysteine-type endopeptidase activity involved in apoptotic process and molecular function this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :0097194 and execution phase of apoptosis and biological process this GO :0097199 and cysteine-type endopeptidase activity involved in apoptotic signaling pathway and molecular function this GO :0097202 and activation of cysteine-type endopeptidase activity and biological process this GO :0097284 and hepatocyte apoptotic process and biological process this GO :0097342 and ripoptosome and cellular component this GO :1900740 and positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway and biological process this GO :2001233 and regulation of apoptotic signaling pathway and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, nuclei, this GO :0001525 and angiogenesis and biological process this GO :0001841 and neural tube formation and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004175 and endopeptidase activity and molecular function this GO :0004197 and cysteine-type endopeptidase activity and molecular function this GO :0005123 and death receptor binding and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005815 and microtubule organizing center and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0006508 and proteolysis and biological process this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006921 and cellular component disassembly involved in execution phase of apoptosis and biological process this GO :0007507 and heart development and biological process this GO :0008233 and peptidase activity and molecular function this GO :0008234 and cysteine-type peptidase activity and molecular function this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0009409 and response to cold and biological process this GO :0016032 and viral process and biological process this GO :0030101 and natural killer cell activation and biological process this GO :0030225 and macrophage differentiation and biological process this GO :0030690 and Noc1p-Noc2p complex and cellular component this GO :0031264 and death-inducing signaling complex and cellular component this GO :0031265 and CD95 death-inducing signaling complex and cellular component this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032025 and response to cobalt ion and biological process this GO :0032355 and response to estradiol and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032496 and response to lipopolysaccharide and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034612 and response to tumor necrosis factor and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035872 and nucleotide-binding domain, this GO :0001916 and positive regulation of T cell mediated cytotoxicity and biological process this GO :0002020 and protease binding and molecular function this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0002821 and positive regulation of adaptive immune response and biological process this GO :0005123 and death receptor binding and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0016032 and viral process and biological process this GO :0031264 and death-inducing signaling complex and cellular component this GO :0031265 and CD95 death-inducing signaling complex and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0032729 and positive regulation of interferon-gamma production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0032760 and positive regulation of tumor necrosis factor production and biological process this GO :0032813 and tumor necrosis factor receptor superfamily binding and molecular function this GO :0033077 and T cell differentiation in thymus and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035877 and death effector domain binding and molecular function this GO :0036462 and TRAIL-activated apoptotic signaling pathway and biological process this GO :0042104 and positive regulation of activated T cell proliferation and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043005 and neuron projection and cellular component this GO :0043029 and T cell homeostasis and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0044297 and cell body and cellular component this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045651 and positive regulation of macrophage differentiation and biological process this GO :0045862 and positive regulation of proteolysis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048535 and lymph node development and biological process this GO :0048536 and spleen development and biological process this GO :0048538 and thymus development and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051607 and defense response to virus and biological process this GO :0060340 and positive regulation of type I interferon-mediated signaling pathway and biological process this GO :0060546 and negative regulation of necroptotic process and biological process this GO :0070236 and negative regulation of activation-induced cell death of T cells and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0097049 and motor neuron apoptotic process and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097202 and activation of cysteine-type endopeptidase activity and biological process this GO :0097342 and ripoptosome and cellular component this GO :0097527 and necroptotic signaling pathway and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2000454 and positive regulation of CD8-positive, this GO :0002020 and protease binding and molecular function this GO :0004197 and cysteine-type endopeptidase activity and molecular function this GO :0005123 and death receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006508 and proteolysis and biological process this GO :0006915 and apoptotic process and biological process this GO :0007519 and skeletal muscle tissue development and biological process this GO :0008047 and enzyme activator activity and molecular function this GO :0008234 and cysteine-type peptidase activity and molecular function this GO :0014732 and skeletal muscle atrophy and biological process this GO :0014842 and regulation of satellite cell proliferation and biological process this GO :0014866 and skeletal myofibril assembly and biological process this GO :0016032 and viral process and biological process this GO :0031264 and death-inducing signaling complex and cellular component this GO :0031265 and CD95 death-inducing signaling complex and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0035877 and death effector domain binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043085 and positive regulation of catalytic activity and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043403 and skeletal muscle tissue regeneration and biological process this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0060544 and regulation of necroptotic process and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097342 and ripoptosome and cellular component this GO :1901740 and negative regulation of myoblast fusion and biological process this GO :1902042 and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2001237 and negative regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, this GO :0002020: protease binding, this GO :0002020: protease binding, this GO :0002020: protease binding and also this GO :0004197: cysteine-type endopeptidase activity and also this GO :0005123: death receptor binding and also this GO :0005515: protein binding and also this GO :0008047: enzyme activator activity and also this GO :0008234: cysteine-type peptidase activity and also this GO :0032403: protein complex binding and also this GO :0035877: death effector domain binding, this GO :0002020: protease binding and also this GO :0005123: death receptor binding and also this GO :0005164: tumor necrosis factor receptor binding and also this GO :0005515: protein binding and also this GO :0032403: protein complex binding and also this GO :0032813: tumor necrosis factor receptor superfamily binding and also this GO :0035877: death effector domain binding and also this GO :0042802: identical protein binding, this GO :0004175: endopeptidase activity, this GO :0004175: endopeptidase activity and also this GO :0004197: cysteine-type endopeptidase activity and also this GO :0005123: death receptor binding and also this GO :0005164: tumor necrosis factor receptor binding and also this GO :0005515: protein binding and also this GO :0008233: peptidase activity and also this GO :0008234: cysteine-type peptidase activity and also this GO :0031625: ubiquitin protein ligase binding and also this GO :0032403: protein complex binding and also this GO :0035877: death effector domain binding and also this GO :0046982: protein heterodimerization activity and also this GO :0097110: scaffold protein binding and also this GO :0097153: cysteine-type endopeptidase activity involved in apoptotic process and also this GO :0097199: cysteine-type endopeptidase activity involved in apoptotic signaling pathway, this GO :0004197: cysteine-type endopeptidase activity, this GO :0004197: cysteine-type endopeptidase activity, this GO :0005123: death receptor binding, this GO :0005123: death receptor binding, this GO :0005123: death receptor binding, this GO :0005164: tumor necrosis factor receptor binding, this GO :0005164: tumor necrosis factor receptor binding, this GO :0005515: protein binding, this GO :0005515: protein binding, this GO :0005515: protein binding, this GO :0008047: enzyme activator activity, this GO :0008233: peptidase activity, this GO :0008234: cysteine-type peptidase activity, this GO :0008234: cysteine-type peptidase activity, this GO :0031625: ubiquitin protein ligase binding, this GO :0032403: protein complex binding, this GO :0032403: protein complex binding, this GO :0032403: protein complex binding, this GO :0032813: tumor necrosis factor receptor superfamily binding, this GO :0035877: death effector domain binding, this GO :0035877: death effector domain binding, this GO :0035877: death effector domain binding, this GO :0042802: identical protein binding, this GO :0046982: protein heterodimerization activity, this GO :0097110: scaffold protein binding, this GO :0097153: cysteine-type endopeptidase activity involved in apoptotic process, this GO :0097199: cysteine-type endopeptidase activity involved in apoptotic signaling pathway, Fas (TNFRSF6)-associated via death domain |
| Identity | 1876 |
| Gene | CFLAR |
| Long gene name | CASP8 and FADD like apoptosis regulator |
| Synonyms gene | CASP8AP1 |
| Synonyms gene name | CASP8 and FADD-like apoptosis regulator |
| Synonyms | CASH Casper CLARP FLAME FLIP I-FLICE MRIT c-FLIP |
| Locus | 2q33, 1 |
| Discovery year | 1999-05-07 |
| GenBank acession | AF005774 |
| Entrez gene record | 8837 |
| Pubmed identfication | 9208847 9217161 |
| RefSeq identity | NM_003879 |
| Classification | Endogenous ligands Death effector domain containing Death inducing signaling complex |
| Havana BLAST/BLAT | OTTHUMG00000132819 |
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