| Long name | 143) Monoclonal Antibody, 186, PPARA (1331CT894 |
| Also known as | 143) Monoclonal Antibody, 186, PPARA (1331CT894 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | PPARA |
| Specificity | This is a highly specific antibody against PPARA |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 1331CT894, 143, 186 |
| Source | This PPARA antibody is generated from a mouse immunized with a recombination protein from the human region of human PPARA |
| Gene ID number | 5465 |
| Swiss Prot | Q07869 |
| Tested Applications | FCM, IF, IHC-P, WB |
| Recommended dilutions | FC(1:25), IF(1:25), WB(1:500) |
| Cross reactivity | Mouse, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Activated by oleylethanolamide, Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC), Functions as transcription activator for the ACOX1 and P450 genes, Key regulator of lipid metabolism, May be required for the propagation of clock information to metabolic pathways regulated by PER2, Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids, Regulates the peroxisomal beta-oxidation pathway of fatty acids, Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2, a naturally occurring lipid that regulates satiety, Ligand-activated transcription factor |
| Purification method | This antibody is purified through a protein G column, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | NR1C1, Nuclear receptor subfamily 1 group C member 1, PPAR-alpha, PPARA, PPARalpha, Peroxisome proliferator-activated receptor alpha, hPPAR, PPAR |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 143) Monoclonal, 186, PPARA (1331CT894 |
| Short name | 143) Monoclonal Antibody, 186, PPARA (1331CT894 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | 143) monoclonal (Antibody to), 186, peroxisome proliferator-activated receptor alpha (1331CT894 |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0006629 and lipid metabolic process and biological process this GO :0006631 and fatty acid metabolic process and biological process this GO :0007507 and heart development and biological process this GO :0008144 and drug binding and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008289 and lipid binding and molecular function this GO :0008544 and epidermis development and biological process this GO :0010467 and gene expression and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010745 and negative regulation of macrophage derived foam cell differentiation and biological process this GO :0010871 and negative regulation of receptor biosynthetic process and biological process this GO :0010887 and negative regulation of cholesterol storage and biological process this GO :0010891 and negative regulation of sequestering of triglyceride and biological process this GO :0015908 and fatty acid transport and biological process this GO :0019217 and regulation of fatty acid metabolic process and biological process this GO :0019902 and phosphatase binding and molecular function this GO :0019904 and protein domain specific binding and molecular function this GO :0030522 and intracellular receptor signaling pathway and biological process this GO :0031624 and ubiquitin conjugating enzyme binding and molecular function this GO :0032000 and positive regulation of fatty acid beta-oxidation and biological process this GO :0032091 and negative regulation of protein binding and biological process this GO :0032099 and negative regulation of appetite and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032868 and response to insulin and biological process this GO :0032922 and circadian regulation of gene expression and biological process this GO :0035095 and behavioral response to nicotine and biological process this GO :0042060 and wound healing and biological process this GO :0042157 and lipoprotein metabolic process and biological process this GO :0042752 and regulation of circadian rhythm and biological process this GO :0043401 and steroid hormone mediated signaling pathway and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044255 and cellular lipid metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045722 and positive regulation of gluconeogenesis and biological process this GO :0045776 and negative regulation of blood pressure and biological process this GO :0045820 and negative regulation of glycolytic process and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046321 and positive regulation of fatty acid oxidation and biological process this GO :0051525 and NFAT protein binding and molecular function this GO :0070166 and enamel mineralization and biological process this GO :0072363 and regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0072366 and regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0072369 and regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0097371 and MDM2/MDM4 family protein binding and molecular function this GO :1901215 and negative regulation of neuron death and biological process this GO :2000678 and negative regulation of transcription regulatory region DNA binding and biological process, MDM2/MDM4 family protein binding, PPARA and IDBG-11786 and ENSG00000186951 and 5465, PPARA and IDBG-642347 and ENSBTAG00000008063 and 281992, Ppara and IDBG-170640 and ENSMUSG00000022383 and 19013, hPPAR and NR1C1 and PPAR and PPARalpha, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0001077 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0001078 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and molecular function this GO :0001103 and RNA polymerase II repressing transcription factor binding and molecular function this GO :0001190 and RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0001666 and response to hypoxia and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003707 and steroid hormone receptor activity and molecular function this GO :0004872 and receptor activity and molecular function this GO :0004879 and ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0006355 and regulation of transcription, this GO :0000978: RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0000978: RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and also this GO :0001078: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and also this GO :0001103: RNA polymerase II repressing transcription factor binding and also this GO :0001190: RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription and also this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0003707: steroid hormone receptor activity and also this GO :0004872: receptor activity and also this GO :0004879: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0005515: protein binding and also this GO :0008144: drug binding and also this GO :0008270: zinc ion binding and also this GO :0008289: lipid binding and also this GO :0019902: phosphatase binding and also this GO :0019904: protein domain specific binding and also this GO :0031624: ubiquitin conjugating enzyme binding and also this GO :0032403: protein complex binding and also this GO :0043565: sequence-specific DNA binding and also this GO :0051525: NFAT protein binding and also this GO :0097371: MDM2/MDM4 family protein binding, this GO :0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, this GO :0001078: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription, this GO :0001103: RNA polymerase II repressing transcription factor binding, this GO :0001190: RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription, this GO :0003677: DNA binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0003707: steroid hormone receptor activity, this GO :0004872: receptor activity, this GO :0004879: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0005515: protein binding, this GO :0008144: drug binding, this GO :0008270: zinc ion binding, this GO :0008289: lipid binding, this GO :0019902: phosphatase binding, this GO :0019904: protein domain specific binding, this GO :0031624: ubiquitin conjugating enzyme binding, this GO :0032403: protein complex binding, this GO :0043565: sequence-specific DNA binding, this GO :0051525: NFAT protein binding, this GO :0097371: MDM2/MDM4 family protein binding, peroxisome proliferator-activated receptor alpha |
| Identity | 9232 |
| Gene | PPARA |
| Long gene name | peroxisome proliferator activated receptor alpha |
| Synonyms gene | PPAR |
| Synonyms gene name | alpha peroxisome proliferator-activated receptor alpha , peroxisome proliferative activated receptor |
| Synonyms | hPPAR NR1C1 |
| Locus | 22q13, 31 |
| Discovery year | 1993-11-01 |
| GenBank acession | L02932 |
| Entrez gene record | 5465 |
| Pubmed identfication | 7684926 10591208 |
| RefSeq identity | NM_001001928 |
| Classification | Nuclear hormone receptors |
| Havana BLAST/BLAT | OTTHUMG00000150443 |
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