pRb (7E6) Monoclonal Antibody

pRb (7E6) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 362

Size 0.1ml

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Long name	pRb (7E6) Monoclonal Antibody
Also known as	pRb (7E6) Monoclonal Antibody
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	pRb(retinoblastoma protein)
Specificity	This is a highly specific antibody against pRb(retinoblastoma protein)
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Monoclonal
Clone number	7000000
Concentration	1ug per 1ul
Source	Recombinant human protein purified from E, coli
Gene ID number	5925
Swiss Prot	P06400
Tested Applications	WB
Recommended dilutions	0 ug), 5 ug/mL) IP (2, WB (0
Cross reactivity	Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	Acts as a transcription repressor of E2F1 target genes, Controls histone H4 'Lys-20' trimethylation, Directly involved in heterochromatin formation by maintaining overall chromatin structure and, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity, In case of viral infections, In resting neurons, Inhibits the intrinsic kinase activity of TAF1, KMT5B and KMT5C, Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter, Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C, RB1 is dephosphorylated by calcineurin, Recruits and targets histone methyltransferases SUV39H1, The underphosphorylated, Upon calcium influx, active form of RB1 interacts with E2F1 and represses its transcription activity, in particular, interactions with SV40 large T antigen, leading to cell cycle arrest, leading to epigenetic transcriptional repression, that of constitutive heterochromatin by stabilizing histone methylation, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex, which leads to release of the repressor complex (By similarity), Key regulator of entry into cell division that acts as a tumor suppressor
Purification method	Purified by Protein G
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	OSRC, PPP1R130, RB1, Retinoblastoma-associated protein, p105-Rb, pRb, pp110, RB
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About	Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target	pRb (7E6) Monoclonal
Short name	pRb (7E6) Monoclonal Antibody
Technique	Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name	pRb (7E6) monoclonal (Antibody to)
Alternative technique	antibodies

pRb (7E6) Monoclonal Antibody

pRb (7E6) Monoclonal Antibody size: 0.1ml 362

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