| Long name | 1, 6) Monoclonal Antibody, PRKAA1 (167CT22 |
| Also known as | 1, 6) Monoclonal Antibody, PRKAA1 (167CT22 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | PRKAA1 |
| Specificity | This is a highly specific antibody against PRKAA1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 1, 167CT22, 6 |
| Source | This PRKAA1 Monoclonal antibody was raised using purified His-tagged recombinant human PRKAA1 |
| Gene ID number | 5562 |
| Swiss Prot | Q13131 |
| Tested Applications | IHC-P, WB |
| Recommended dilutions | IHC-P(1:50~100), WB(1:1000) |
| Cross reactivity | Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia, It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase, This is a catalytic subunit, Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase |
| Purification method | 09% (W/V) sodium azide, Mouse monoclonal antibody supplied in crude ascites with 0 |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | 5'-AMP-activated protein kinase catalytic subunit alpha-1, ACACA kinase, AMPK subunit alpha-1, AMPK1, AMPKa1, Acetyl-CoA carboxylase kinase, HMGCR kinase, Hydroxymethylglutaryl-CoA reductase kinase, PRKAA1, Tau-protein kinase PRKAA1, AMPK |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 1, 6) Monoclonal, PRKAA1 (167CT22 |
| Short name | 1, 6) Monoclonal Antibody, PRKAA1 (167CT22 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | AMP-activated, a 1 catalytic subunit (167CT22, 1, 6) monoclonal (Antibody to), protein phosphorylation catalyst |
| Alternative technique | antibodies |
| Alternative to gene target | AMP-activated, AMPK and AMPKa1, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006633 and fatty acid biosynthetic process and biological process this GO :0006695 and cholesterol biosynthetic process and biological process this GO :0006914 and autophagy and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007165 and signal transduction and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008610 and lipid biosynthetic process and biological process this GO :0009411 and response to UV and biological process this GO :0009631 and cold acclimation and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0010508 and positive regulation of autophagy and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0014823 and response to activity and biological process this GO :0016055 and Wnt signaling pathway and biological process this GO :0016324 and apical plasma membrane and cellular component this GO :0016772 and transferase activity, PRKAA1 and IDBG-18226 and ENSG00000132356 and 5562, PRKAA1 and IDBG-629895 and ENSBTAG00000000013 and 540404, Prkaa1 and IDBG-128002 and ENSMUSG00000050697 and 105787, alpha 1 catalytic subunit, nuclei, this GO :0000187 and activation of MAPK activity and biological process this GO :0001666 and response to hypoxia and biological process this GO :0003682 and chromatin binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004679 and AMP-activated protein kinase activity and molecular function this GO :0004691 and cAMP-dependent protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006006 and glucose metabolic process and biological process this GO :0006351 and transcription, this GO :0003682: chromatin binding, this GO :0003682: chromatin binding and also this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004679: AMP-activated protein kinase activity and also this GO :0004691: cAMP-dependent protein kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0008022: protein C-terminus binding and also this GO :0016772: transferase activity, this GO :0004672: protein kinase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004679: AMP-activated protein kinase activity, this GO :0004691: cAMP-dependent protein kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0008022: protein C-terminus binding, this GO :0016772: transferase activity, this GO :0019900: kinase binding, this GO :0035174: histone serine kinase activity, this GO :0046872: metal ion binding, this GO :0047322: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity, this GO :0050321: tau-protein kinase activity, this GO :0050405: [acetyl-CoA carboxylase] kinase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019900: kinase binding and also this GO :0035174: histone serine kinase activity and also this GO :0046872: metal ion binding and also this GO :0047322: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity and also this GO :0050321: tau-protein kinase activity and also this GO :0050405: [acetyl-CoA carboxylase] kinase activity, transferring phosphorus-containing groups and molecular function this GO :0019395 and fatty acid oxidation and biological process this GO :0019900 and kinase binding and molecular function this GO :0031000 and response to caffeine and biological process this GO :0031588 and AMP-activated protein kinase complex and cellular component this GO :0031669 and cellular response to nutrient levels and biological process this GO :0032007 and negative regulation of TOR signaling and biological process this GO :0035174 and histone serine kinase activity and molecular function this GO :0035404 and histone-serine phosphorylation and biological process this GO :0042149 and cellular response to glucose starvation and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0042593 and glucose homeostasis and biological process this GO :0042752 and regulation of circadian rhythm and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0045542 and positive regulation of cholesterol biosynthetic process and biological process this GO :0045821 and positive regulation of glycolytic process and biological process this GO :0046318 and negative regulation of glucosylceramide biosynthetic process and biological process this GO :0046872 and metal ion binding and molecular function this GO :0047322 and [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity and molecular function this GO :0048511 and rhythmic process and biological process this GO :0050321 and tau-protein kinase activity and molecular function this GO :0050405 and [acetyl-CoA carboxylase] kinase activity and molecular function this GO :0050995 and negative regulation of lipid catabolic process and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0055089 and fatty acid homeostasis and biological process this GO :0060627 and regulation of vesicle-mediated transport and biological process this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0071361 and cellular response to ethanol and biological process this GO :0071417 and cellular response to organonitrogen compound and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :1901563 and response to camptothecin and biological process this GO :2000505 and regulation of energy homeostasis and biological process this GO :2001274 and negative regulation of glucose import in response to insulin stimulus and biological process, protein kinase |
| Identity | 9376 |
| Gene | PRKAA1 |
| Long gene name | protein kinase AMP-activated catalytic subunit alpha 1 |
| Synonyms gene name | AMP-activated, alpha 1 catalytic subunit , protein kinase |
| Synonyms | AMPKa1 |
| Synonyms name | 1 , AMPK, alpha |
| Locus | 5p13, 1 |
| Discovery year | 1997-05-09 |
| Entrez gene record | 5562 |
| Pubmed identfication | 8557660 |
| RefSeq identity | NM_006251 |
| Havana BLAST/BLAT | OTTHUMG00000162269 |
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