| Long name | PRKCQ(Thr538) Primary Polyclonal Antibody |
| Also known as | PRKCQ(Thr538) PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | PRKCQ Thr538 |
| Specificity | This is a highly specific antibody against PRKCQ Thr538 |
| Modification(s) | Phosphorylation |
| Modification site(s) | Thr538 |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 532-540/706 |
| Subcellular location | Cytoplasm |
| Source | KLH conjugated synthetic phosphopeptide derived from human PRKCQ around the phosphorylation site of Thr538 |
| Gene ID number | 5588 |
| Swiss Prot | Q04759 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, During T-cells differentiation, In TCR-CD3/CD28-co-stimulated T-cells, In the signaling pathway leading to JUN activation, JUN, May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway, May play a minor role in Th1 response, Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, NFATC1 and NFATC2, Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling, and, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation, by mediating activation of multiple transcription factors such as NF-kappa-B, differentiation and survival, in the development of inflammatory autoimmune diseases, including T-cells activation, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, is necessary for the activation of IL17-producing Th17 cells, is required for the activation of NF-kappa-B and JUN, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, proliferation, resulting in nuclear translocation and activation of NFKB1, which in turn are essential for IL2 production, which is a prerequisite for the activation of TCR, which then activates IKK complex, 4, 5-trisphosphate generation and intracellular calcium mobilization, Calcium-independent |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | PRKCQ, Protein kinase C theta type, nPKC-theta, PRKCT |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | PRKCQ(Thr538) |
| Short name | PRKCQ(Thr538) Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | theta(Thr538) (Antibody to), protein kinase C |
| Alternative technique | antibodies |
| Alternative to gene target | Cell surfaces, DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006509 and membrane protein ectodomain proteolysis and biological process this GO :0006915 and apoptotic process and biological process this GO :0006921 and cellular component disassembly involved in execution phase of apoptosis and biological process this GO :0006954 and inflammatory response and biological process this GO :0007411 and axon guidance and biological process this GO :0007596 and blood coagulation and biological process this GO :0007603 and phototransduction, PRKCQ and IDBG-51302 and ENSG00000065675 and 5588, PRKCQ and IDBG-637023 and ENSBTAG00000010664 and 505901, Prkcq and IDBG-136196 and ENSMUSG00000026778 and 18761, nPKC-theta and PRKCT, theta, this GO :0001558 and regulation of cell growth and biological process this GO :0001772 and immunological synapse and cellular component this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004697 and protein kinase C activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006355 and regulation of transcription, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004697: protein kinase C activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004842: ubiquitin-protein transferase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004697: protein kinase C activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004842: ubiquitin-protein transferase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, this GO :0046872: metal ion binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0046872: metal ion binding, transferring phosphorus-containing groups and molecular function this GO :0022400 and regulation of rhodopsin mediated signaling pathway and biological process this GO :0030168 and platelet activation and biological process this GO :0032740 and positive regulation of interleukin-17 production and biological process this GO :0032753 and positive regulation of interleukin-4 production and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0045086 and positive regulation of interleukin-2 biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0046627 and negative regulation of insulin receptor signaling pathway and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050870 and positive regulation of T cell activation and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0070233 and negative regulation of T cell apoptotic process and biological process this GO :0090330 and regulation of platelet aggregation and biological process this GO :2000318 and positive regulation of T-helper 17 type immune response and biological process this GO :2000570 and positive regulation of T-helper 2 cell activation and biological process, visible light and biological process this GO :0016056 and rhodopsin mediated signaling pathway and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0016772 and transferase activity, protein kinase C |
| Identity | 9410 |
| Gene | PRKCQ |
| Long gene name | protein kinase C theta |
| Synonyms gene name | protein kinase C, theta |
| Locus | 10p15, 1 |
| Discovery year | 1992-12-14 |
| GenBank acession | L07032 |
| Entrez gene record | 5588 |
| Pubmed identfication | 8444877 |
| RefSeq identity | NM_006257 |
| Classification | C2 domain containing protein kinases |
| Havana BLAST/BLAT | OTTHUMG00000017623 |
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