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Prostate-Specific Membrane Antigen Antibody (PSMA)

Prostate-Specific Membrane Antigen Antibody (PSMA) size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenProstate-Specific Membrane Antigen (PSMA)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IHC, WB, IF
Recommended dilutionsIHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50, Western blot: 1:1000
NotesTitration of the PSMA antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis PSMA antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q04609
PurityAntigen affinity
Description All of which refer to the same protein, GCPII is a class II membrane glycoprotein, In cancer, In human prostate cancer, It catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA), Most of the enzyme resides in the extracellular space, Neuroscientists primarily use the term NAALADase in their studies, PSMA, PSMA is strongly expressed in the human prostate, [Wiki], and those studying prostate cancer or oncology, being a hundredfold greater than the expression in most other tissues, glutamate carboxypeptidase II, it is upregulated in expression and has been called the second-most-upregulated gene in prostate cancer, the higher expressing tumors are associated with quicker time to progression and a greater percentage of patients suffering relapse, while those studying folate metabolism use folate hydrolase, with increase of 8- to 12-fold over the noncancerous prostate, GCPII is a zinc metalloenzyme that resides in membranes
ImmunogenA portion of amino acids 161-190 from the human protein was used as the immunogen for this PSMA antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the PSMA antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetProstate-Specific Membrane (PSMA)
Short nameProstate-Specific Membrane Antigen Antibody (PSMA)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameProstate-Specific Membrane protein (Antibody to) (PSMA)
Alternative techniqueantibodies
Identity 3788
Gene FOLH1
Long gene name folate hydrolase 1
Synonyms gene FOLH
Synonyms gene name folate hydrolase (prostate-specific membrane antigen) 1
Synonyms PSM PSMA NAALAD1 NAALAdase GCP2 GCPII
Synonyms name glutamate carboxylase II glutamate carboxypeptidase 2
Locus 11p11, 12
Discovery year 1996-12-16
GenBank acession M99487
Entrez gene record 2346
Pubmed identfication 9838072
RefSeq identity NM_004476
Havana BLAST/BLAT OTTHUMG00000166625

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