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Protein kinase C beta IsoformII Antibody, Cy5.5 Conjugated

Protein kinase C beta IsoformII Antibody, Cy5.5 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy5, 5 Conjugated, Protein kinase C beta IsoformII Antibody
CategoryConjugated Primary Antibodies
Conjugation Cy5, 5, 5, Cy5
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenPKC beta
Specificity This antibody will recognize isoform Beta-II of Protein kinase C beta, This is a highly specific antibody against PKC beta
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range620-673/673
Subcellular location Cell membrane, Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human PKC beta 2
Gene ID number5579
Swiss ProtP05771
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background 'Ser-644' and 'Ser-652', Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, In insulin signaling, Involved in apoptosis following oxidative damage: in case of oxidative conditions, May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4, Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, Plays a direct role in the negative feedback regulation of the BCR signaling, Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation, a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A, androgen receptor-dependent transcription regulation, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', insulin signaling and endothelial cells proliferation, leading to mitochondrial accumulation of p66Shc, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade, oxidative stress-induced apoptosis, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, resulting in nuclear translocation and activation of NFKB1, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, where p66Shc acts as a reactive oxygen species producer, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity, which then activates IKK complex, Calcium-activated
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission675nm/694nm
Synonyms PKC-B, PKC-beta, PRKCB, PRKCB1, PRKCB2, Protein kinase C beta type, PKCB
Properties Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths
Gene targetProtein kinase C beta IsoformII Conjugated
Short name Conjugated, Protein kinase C beta IsoformII Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label5, Cy5
Alternative name cyanine 5, 5 coupled, Protein phosphorylation catalyst C b IsoformII (Antibody to)
Alternative techniqueantibodies

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