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Protein kinase C beta IsoformII Antibody, FITC Conjugated

Protein kinase C beta IsoformII Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, Protein kinase C beta IsoformII Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenPKC beta
Specificity This antibody will recognize isoform Beta-II of Protein kinase C beta, This is a highly specific antibody against PKC beta
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range620-673/673
Subcellular location Cell membrane, Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human PKC beta 2
Gene ID number5579
Swiss ProtP05771
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background 'Ser-644' and 'Ser-652', Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, In insulin signaling, Involved in apoptosis following oxidative damage: in case of oxidative conditions, May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4, Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, Plays a direct role in the negative feedback regulation of the BCR signaling, Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation, a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A, androgen receptor-dependent transcription regulation, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', insulin signaling and endothelial cells proliferation, leading to mitochondrial accumulation of p66Shc, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade, oxidative stress-induced apoptosis, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, resulting in nuclear translocation and activation of NFKB1, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, where p66Shc acts as a reactive oxygen species producer, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity, which then activates IKK complex, Calcium-activated
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms PKC-B, PKC-beta, PRKCB, PRKCB1, PRKCB2, Protein kinase C beta type, PKCB
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetProtein kinase C beta IsoformII Conjugated
Short name FITC Conjugated, Protein kinase C beta IsoformII Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, Protein phosphorylation catalyst C b IsoformII (Antibody to)
Alternative techniqueantibodies

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