| Long name | 145) Monoclonal Antibody, 163, PTK2 (1297CT261 |
| Also known as | 145) Monoclonal Antibody, 163, PTK2 (1297CT261 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | PTK2 |
| Specificity | This is a highly specific antibody against PTK2 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 1297CT261, 145, 163 |
| Source | This PTK2 antibody is generated from a mice immunized with a recombinant protein between 1-128 amino acids from the N-terminal region of human PTK2 |
| Gene ID number | 5747 |
| Swiss Prot | Q05397 |
| Tested Applications | WB |
| Recommended dilutions | WB(1:1000) |
| Cross reactivity | Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | EPHA2, Forms multisubunit signaling complexes with SRC and SRC family members upon activation, Functions in integrin signal transduction, G-protein coupled receptors (GPCR), MAPK3/ERK1 and the MAP kinase signaling cascade, P53/TP53 ubiquitination and proteasomal degradation, Phosphorylates SRC, Plays a role in osteogenesis and differentiation of osteoblasts, Promotes activation of MAPK1/ERK2, Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade, Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, Regulates axon growth and neuronal cell migration, Regulates numerous signaling pathways, Required for early embryonic development and placenta development, Required for embryonic angiogenesis, Signaling via CAS family members mediates activation of RAC1, adhesion, and normal heart development, and thereby modulates the activity of Rho family GTPases, and thereby regulates P53/TP53 activity, axon branching and synapse formation, but also in signaling downstream of numerous growth factor receptors, cell cycle progression, cell proliferation and apoptosis, creating binding sites for scaffold proteins, effectors and substrates, formation and disassembly of focal adhesions and cell protrusions, netrin receptors and LDL receptors, normal cardiomyocyte migration and proliferation, reorganization of the actin cytoskeleton, required for normal development of the nervous system, spreading, this increases SRC kinase activity, this leads to the phosphorylation of additional tyrosine residues, Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration |
| Purification method | This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | FADK, FADK 1, FAK1, FRNK, Focal adhesion kinase 1, Focal adhesion kinase-related nonkinase, PPP1R71, PTK2, Protein phosphatase 1 regulatory subunit 71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, FAK |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 145) Monoclonal, 163, PTK2 (1297CT261 |
| Short name | 145) Monoclonal Antibody, 163, PTK2 (1297CT261 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | 145) monoclonal (Antibody to), 163, PTK2 protein tyrosine kinase 2 (1297CT261 |
| Alternative technique | antibodies |
| Alternative to gene target | FADK and FAK and FAK1 and FRNK and p125FAK and pp125FAK and PPP1R71, PTK2 and IDBG-37147 and ENSG00000169398 and 5747, PTK2 and IDBG-643924 and ENSBTAG00000009578 and 506270, Ptk2 and IDBG-148322 and ENSMUSG00000022607 and 14083, nuclei, this GO :0000226 and microtubule cytoskeleton organization and biological process this GO :0001525 and angiogenesis and biological process this GO :0001568 and blood vessel development and biological process this GO :0001570 and vasculogenesis and biological process this GO :0001764 and neuron migration and biological process this GO :0001890 and placenta development and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0003007 and heart morphogenesis and biological process this GO :0003779 and actin binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005815 and microtubule organizing center and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0005938 and cell cortex and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0006921 and cellular component disassembly involved in execution phase of apoptosis and biological process this GO :0007165 and signal transduction and biological process this GO :0007172 and signal complex assembly and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007411 and axon guidance and biological process this GO :0007596 and blood coagulation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008360 and regulation of cell shape and biological process this GO :0008432 and JUN kinase binding and molecular function this GO :0009790 and embryo development and biological process this GO :0010594 and regulation of endothelial cell migration and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016324 and apical plasma membrane and cellular component this GO :0016772 and transferase activity, this GO :0003779: actin binding, this GO :0003779: actin binding and also this GO :0004672: protein kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004715: non-membrane spanning protein tyrosine kinase activity and also this GO :0004871: signal transducer activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0008432: JUN kinase binding and also this GO :0016772: transferase activity, this GO :0004672: protein kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004715: non-membrane spanning protein tyrosine kinase activity, this GO :0004871: signal transducer activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0008432: JUN kinase binding, this GO :0016772: transferase activity, this GO :0019901: protein kinase binding, this GO :0042169: SH2 domain binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019901: protein kinase binding and also this GO :0042169: SH2 domain binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0021955 and central nervous system neuron axonogenesis and biological process this GO :0022408 and negative regulation of cell-cell adhesion and biological process this GO :0030010 and establishment of cell polarity and biological process this GO :0030027 and lamellipodium and cellular component this GO :0030168 and platelet activation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0032319 and regulation of Rho GTPase activity and biological process this GO :0033628 and regulation of cell adhesion mediated by integrin and biological process this GO :0038007 and netrin-activated signaling pathway and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0040023 and establishment of nucleus localization and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043542 and endothelial cell migration and biological process this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045667 and regulation of osteoblast differentiation and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0046621 and negative regulation of organ growth and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048013 and ephrin receptor signaling pathway and biological process this GO :0048870 and cell motility and biological process this GO :0050771 and negative regulation of axonogenesis and biological process this GO :0051493 and regulation of cytoskeleton organization and biological process this GO :0051893 and regulation of focal adhesion assembly and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0051964 and negative regulation of synapse assembly and biological process this GO :0060396 and growth hormone receptor signaling pathway and biological process this GO :2000060 and positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process and biological process this GO :2000811 and negative regulation of anoikis and biological process, PTK2 protein tyrosine kinase 2 |
| Identity | 9611 |
| Gene | PTK2 |
| Long gene name | protein tyrosine kinase 2 |
| Synonyms gene name | PTK2 protein tyrosine kinase 2 |
| Synonyms | FAK FADK FAK1 PPP1R71 |
| Synonyms name | protein phosphatase 1, regulatory subunit 71 |
| Locus | 8q24, 3 |
| Discovery year | 1992-10-02 |
| GenBank acession | L13616 |
| Entrez gene record | 5747 |
| Pubmed identfication | 8422239 |
| RefSeq identity | NM_005607 |
| Classification | Protein phosphatase 1 regulatory subunits FERM domain containing |
| Havana BLAST/BLAT | OTTHUMG00000067438 |
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