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PTPN5/STEP Antibody

PTPN5/STEP Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePTPN5/STEP Primary Polyclonal Antibody
Also known asPTPN5/STEP PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPTPN5/STEP
SpecificityThis is a highly specific antibody against PTPN5/STEP
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PTPN5
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Isolated from mouse brain, STEP depresses both NMDAR single-channel activity and synaptic currents, STEP family members are expressed in the dopaminoceptive neurons of the CNS, STEP61 contains a single tyrosine phosphatase domain, STEP61 dephosphorylates Tyr-420 residue and may thus regulate Fyn activity in PSDs, The STEP protein regulates the N-methyl-d-aspartate receptor (NMDAR) complex, The STEP61 protein associates with the Src family kinase member Fyn when Fyn is phosphorylated at Tyr-420 and not Tyr-431, The human STEP gene maps to chromosome 11p15, The membrane-associated STEP61 isoform localizes in the postsynaptic densities (PSDs) of striatal neurons, Upon association, the STEP20 isoform lacks the conserved tyrosine phosphatase domain, two proline-rich domains and two transmembrane domains, with highest expression in the basal ganglia and related structures, 1, 2-p15, The brain-specific STEP (striatal enriched phosphatase) family of protein tyrosine phosphatases (PTPs) comprises both transmembrane and cytosolic protein members which are the products of alternative splicing
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names FLJ14427, Neural-specic protein-tyrosine phosphatase, PTN5, PTN5_HUMAN, PTP STEP, PTPN 5, PTPSTEP, Protein tyrosine phosphatase non receptor type 5, Protein tyrosine phosphatase non receptor type 5 striatum enriched, Protein tyrosine phosphatase striatum enriched, Ptpn5, STEP, Striatum-enriched protein-tyrosine phosphatase, Tyrosine protein phosphatase non receptor type 5, Tyrosine-protein phosphatase non-receptor type 5, Neural specic protein tyrosine phosphatase
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetPTPN5/
Short namePTPN5/STEP Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePTPN5/STEP (Antibody to)
Alternative techniqueantibodies
Identity 9657
Gene PTPN5
Long gene name non-receptor type 5 , protein tyrosine phosphatase
Synonyms gene name non-receptor type 5 (striatum-enriched) , protein tyrosine phosphatase
Synonyms STEP PTPSTEP STEP61
Synonyms name striatal-enriched protein tyrosine phosphatase
Locus 11p15, 1
Discovery year 1992-02-12
GenBank acession BC064807
Entrez gene record 84867
Pubmed identfication 1714595
RefSeq identity NM_001039970
Classification Protein tyrosine phosphatases, non-receptor type
Havana BLAST/BLAT OTTHUMG00000134304

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