| Long name | Cy3 Conjugated, PTPN6(Ser591) Polyclonal Antibody |
| Category | Conjugated Primary Antibodies |
| Conjugation | cy3 conjugation kit |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | PTPN6 Ser591 |
| Specificity | This is a highly specific antibody against PTPN6 Ser591 |
| Modification | Phosphorylation |
| Modification site | Ser591 |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen_range | 570-595/595 |
| Subcellular location | Nucleus, Cytoplasm |
| Source | KLH conjugated synthetic phosphopeptide derived from human PTPN6 around the phosphorylation site of Ser591 [KG(p-S)LK] |
| Gene ID number | 5777 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Rat, Human |
| Crossreactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background | PTP1B is cytosolic, SHP1 is implicated in the control of tyrosine kinase signalling pathways in cellular proliferation, The PTP family comprises of at least 37 proteins, The PTPs have high substrate specificity for phosphotyrosyl proteins, and includes both transmembrane and cytosolic enzymes, at the primary sequence level sharing little similarity with the protein serine phosphatases, characterized by a catalytic phosphatase domain of approximately 240 amino acids, or the acid and alkaline phosphatases, protein threonine phosphatases, with a potential role in cancer, SHP1 is a member of the non receptor protein tyrosine phosphatase subfamily |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission | 512, 550nm/570, 615nm |
| Synonyms | HCP HCPH PTP-1C SHP-1 SHP1 |
| Properties | 1 of the PTPN6(Ser591) Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target | PTPN6(Ser591) Conjugated |
| Short name | Conjugated, PTPN6(Ser591) Antibody |
| Technique | antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label | Cy3 |
| Alternative name | cyanine 3 coupled, non-receptor classification 6(Ser591) (Antibody to), protein tyrosine phosphatase |
| Alternative technique | antibodies |
| Alternative to gene target | HCP and HCPH and HPTP1C and PTP-1C and SH-PTP1 and SHP-1 and SHP-1L and SHP1, PTPN6 and IDBG-15719 and ENSG00000111679 and 5777, PTPN6 and IDBG-640141 and ENSBTAG00000020294 and 512312, Ptpn6 and IDBG-187635 and ENSMUSG00000004266 and 15170, SH2 domain binding, non-receptor type 6, nuclei, this GO :0001784 and phosphotyrosine binding and molecular function this GO :0002244 and hematopoietic progenitor cell differentiation and biological process this GO :0002924 and negative regulation of humoral immune response mediated by circulating immunoglobulin and biological process this GO :0004725 and protein tyrosine phosphatase activity and molecular function this GO :0005001 and transmembrane receptor protein tyrosine phosphatase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0006470 and protein dephosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007596 and blood coagulation and biological process this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016311 and dephosphorylation and biological process this GO :0016791 and phosphatase activity and molecular function this GO :0017124 and SH3 domain binding and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0030154 and cell differentiation and biological process this GO :0030220 and platelet formation and biological process this GO :0031295 and T cell costimulation and biological process this GO :0033277 and abortive mitotic cell cycle and biological process this GO :0033630 and positive regulation of cell adhesion mediated by integrin and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0035855 and megakaryocyte development and biological process this GO :0042105 and alpha-beta T cell receptor complex and cellular component this GO :0042130 and negative regulation of T cell proliferation and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0042267 and natural killer cell mediated cytotoxicity and biological process this GO :0043407 and negative regulation of MAP kinase activity and biological process this GO :0043409 and negative regulation of MAPK cascade and biological process this GO :0045087 and innate immune response and biological process this GO :0045577 and regulation of B cell differentiation and biological process this GO :0050732 and negative regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0050859 and negative regulation of B cell receptor signaling pathway and biological process this GO :0050860 and negative regulation of T cell receptor signaling pathway and biological process this GO :0050900 and leukocyte migration and biological process this GO :0051279 and regulation of release of sequestered calcium ion into cytosol and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060334 and regulation of interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0060338 and regulation of type I interferon-mediated signaling pathway and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070372 and regulation of ERK1 and ERK2 cascade and biological process this GO :0070527 and platelet aggregation and biological process this GO :2000045 and regulation of G1/S transition of mitotic cell cycle and biological process, this GO :0001784: phosphotyrosine binding, this GO :0001784: phosphotyrosine binding and also this GO :0004725: protein tyrosine phosphatase activity and also this GO :0005001: transmembrane receptor protein tyrosine phosphatase activity and also this GO :0005515: protein binding and also this GO :0016791: phosphatase activity and also this GO :0017124: SH3 domain binding and also this GO :0019901: protein kinase binding and also this GO :0042169: SH2 domain binding, this GO :0004725: protein tyrosine phosphatase activity, this GO :0005001: transmembrane receptor protein tyrosine phosphatase activity, this GO :0005515: protein binding, this GO :0016791: phosphatase activity, this GO :0017124: SH3 domain binding, this GO :0019901: protein kinase binding, this GO :0042169: SH2 domain binding, protein tyrosine phosphatase |
| Identity | 9658 |
| Gene | PTPN6 |
| Long gene name | non-receptor type 6 , protein tyrosine phosphatase |
| Locus | 12p13, 31 |
| Discovery year | 1992-02-12 |
| Entrez gene record | 5777 |
| Pubmed identfication | 1639416 |
| RefSeq identity | NM_002831 |
| Classification | Protein tyrosine phosphatases, non-receptor type SH2 domain containing |
| Havana BLAST/BLAT | OTTHUMG00000168518 |
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