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Pumilio 1 Antibody

Pumilio 1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long namePumilio 1 Primary Polyclonal Antibody
Also known asPumilio 1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenPumilio 1
SpecificityThis is a highly specific antibody against Pumilio 1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range230-280/1186
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Pumilio 1
Gene ID number9698
Swiss ProtQ14671
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen 5'-UGUANAUA-3', Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517), Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, Binds to an RNA consensus sequence, Following growth factor stimulation, In testis, Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity), Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276), Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845), PubMed:18328718, PubMed:20818387, PubMed:20860814, PubMed:21397187), PubMed:21653694, PubMed:22345517), acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53, and rapid entry to the cell cycle (PubMed:20818387), efficient suppression of CDKN1B/p27 expression, inducing a local conformational change that exposes miRNA-binding sites, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905), phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, promoting association of miR-221 and miR-222, that is related to the Nanos Response Element (NRE) (PubMed:21572425, the Pumilio Response Element (PRE), Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names HSPUM, KIAA0099, PUM1, PUMH1, PUML1, Pumilio homolog 1, Pumilio-1, PUMH
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetPumilio 1
Short namePumilio 1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namePumilio 1 (Antibody to)
Alternative techniqueantibodies
Identity 14957
Gene PUM1
Long gene name pumilio RNA binding family member 1
Synonyms gene name pumilio homolog 1 (Drosophila)
Synonyms PUMH1 KIAA0099
Locus 1p35, 2
Discovery year 2001-03-27
GenBank acession AF315592
Entrez gene record 9698
Havana BLAST/BLAT OTTHUMG00000003795

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