| Long name | 104) Monoclonal Antibody, 121, RAC1 (1301CT276 |
| Also known as | 104) Monoclonal Antibody, 121, RAC1 (1301CT276 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | RAC1 |
| Specificity | This is a highly specific antibody against RAC1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 104, 121, 1301CT276 |
| Source | This antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between amino acids from human |
| Gene ID number | 5879 |
| Swiss Prot | P63000 |
| Tested Applications | FCM, IHC-P, WB |
| Recommended dilutions | FC(1:100), IHC-P(1:25), IHC-P(1:25) |
| Cross reactivity | Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly, In concert with RAB7A, In glioma cells, In its active state, In podocytes, In synapses, Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, Stimulates PKN2 kinase activity, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, epithelial cell polarization and growth-factor induced formation of membrane ruffles, increasing its efficiency in chemokine uptake and degradation, phagocytosis of apoptotic cells, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts, promotes cell migration and invasion, promotes nuclear shuttling of NR3C2, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, suggesting that the insertion does not completely abolish effector interaction, this modulation is required for a proper kidney functioning, which is involved in stimulation of the NADPH oxidase activity in macrophages, which is restored partially by GTPase-activating proteins, Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | Cell migration-inducing gene 5 protein, RAC1, Rac-1, Ras-like protein TC25, Ras-related C3 botulinum toxin substrate 1, TC-25, TC25, p21-Rac1, MIG5 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 104) Monoclonal, 121, RAC1 (1301CT276 |
| Short name | 104) Monoclonal Antibody, 121, RAC1 (1301CT276 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | small GTP binding protein Rac1) (1301CT276, 104) monoclonal (Antibody to), 121, ras-related complement component 3 botulinum toxin substrate 1 (rho family |
| Alternative technique | antibodies |
| Alternative to gene target | Plasma membranes, RAC1 and IDBG-641023 and ENSBTAG00000009233 and 281440, RAC1 and IDBG-8115 and ENSG00000136238 and 5879, Rac1 and IDBG-207763 and ENSMUSG00000001847 and 19353, Rho GDP-dissociation inhibitor binding, engulfment and biological process this GO :0006928 and cellular component movement and biological process this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0006972 and hyperosmotic response and biological process this GO :0007010 and cytoskeleton organization and biological process this GO :0007015 and actin filament organization and biological process this GO :0007155 and cell adhesion and biological process this GO :0007160 and cell-matrix adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0007596 and blood coagulation and biological process this GO :0008283 and cell proliferation and biological process this GO :0009611 and response to wounding and biological process this GO :0009653 and anatomical structure morphogenesis and biological process this GO :0010310 and regulation of hydrogen peroxide metabolic process and biological process this GO :0010592 and positive regulation of lamellipodium assembly and biological process this GO :0015031 and protein transport and biological process this GO :0016020 and membrane and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016032 and viral process and biological process this GO :0016358 and dendrite development and biological process this GO :0016477 and cell migration and biological process this GO :0017137 and Rab GTPase binding and molecular function this GO :0019897 and extrinsic component of plasma membrane and cellular component this GO :0019899 and enzyme binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0021799 and cerebral cortex radially oriented cell migration and biological process this GO :0021831 and embryonic olfactory bulb interneuron precursor migration and biological process this GO :0030027 and lamellipodium and cellular component this GO :0030032 and lamellipodium assembly and biological process this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030041 and actin filament polymerization and biological process this GO :0030168 and platelet activation and biological process this GO :0030334 and regulation of cell migration and biological process this GO :0030742 and GTP-dependent protein binding and molecular function this GO :0030838 and positive regulation of actin filament polymerization and biological process this GO :0031295 and T cell costimulation and biological process this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0031529 and ruffle organization and biological process this GO :0031996 and thioesterase binding and molecular function this GO :0032587 and ruffle membrane and cellular component this GO :0032707 and negative regulation of interleukin-23 production and biological process this GO :0034446 and substrate adhesion-dependent cell spreading and biological process this GO :0035025 and positive regulation of Rho protein signal transduction and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0036464 and cytoplasmic ribonucleoprotein granule and cellular component this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0042470 and melanosome and cellular component this GO :0042995 and cell projection and cellular component this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0043652 and engulfment of apoptotic cell and biological process this GO :0045087 and innate immune response and biological process this GO :0045216 and cell-cell junction organization and biological process this GO :0045453 and bone resorption and biological process this GO :0045740 and positive regulation of DNA replication and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048261 and negative regulation of receptor-mediated endocytosis and biological process this GO :0048532 and anatomical structure arrangement and biological process this GO :0048813 and dendrite morphogenesis and biological process this GO :0048870 and cell motility and biological process this GO :0050690 and regulation of defense response to virus by virus and biological process this GO :0051022 and Rho GDP-dissociation inhibitor binding and molecular function this GO :0051668 and localization within membrane and biological process this GO :0060071 and Wnt signaling pathway, p21-Rac1 and Rac-1 and TC-25, planar cell polarity pathway and biological process this GO :0060263 and regulation of respiratory burst and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071526 and semaphorin-plexin signaling pathway and biological process this GO :0071542 and dopaminergic neuron differentiation and biological process this GO :0072659 and protein localization to plasma membrane and biological process this GO :0090103 and cochlea morphogenesis and biological process this GO :0097178 and ruffle assembly and biological process this GO :0097190 and apoptotic signaling pathway and biological process, small GTP binding protein Rac1), this GO :0000139 and this GO lgi membrane and cellular component this GO :0001891 and pha this GO cytic cup and cellular component this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002093 and auditory receptor cell morphogenesis and biological process this GO :0002551 and mast cell chemotaxis and biological process this GO :0003382 and epithelial cell morphogenesis and biological process this GO :0003924 and GTPase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005525 and GTP binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005802 and trans- this GO lgi network and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006184 and GTP catabolic process and biological process this GO :0006897 and endocytosis and biological process this GO :0006911 and pha this GO cytosis, this GO :0003924: GTPase activity, this GO :0003924: GTPase activity and also this GO :0005515: protein binding and also this GO :0005525: GTP binding and also this GO :0017137: Rab GTPase binding and also this GO :0019899: enzyme binding and also this GO :0019901: protein kinase binding and also this GO :0030742: GTP-dependent protein binding and also this GO :0031996: thioesterase binding and also this GO :0051022: Rho GDP-dissociation inhibitor binding, this GO :0005515: protein binding, this GO :0005525: GTP binding, this GO :0017137: Rab GTPase binding, this GO :0019899: enzyme binding, this GO :0019901: protein kinase binding, this GO :0030742: GTP-dependent protein binding, this GO :0031996: thioesterase binding, this GO :0051022: Rho GDP-dissociation inhibitor binding, ras-related C3 botulinum toxin substrate 1 (rho family |
| Identity | 10044 |
| Gene | RNASE1 |
| Long gene name | pancreatic , ribonuclease A family member 1 |
| Synonyms gene | RNS1 |
| Synonyms gene name | 1 (pancreatic) , RNase A family, ribonuclease |
| Synonyms | RAC1 |
| Locus | 14q11, 2 |
| Discovery year | 1990-02-24 |
| GenBank acession | BC005324 |
| Entrez gene record | 6035 |
| Pubmed identfication | 8588814 |
| Classification | Ribonuclease A family |
| Havana BLAST/BLAT | OTTHUMG00000029603 |
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