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RAD23B (1228CT409.120.123.135) Monoclonal Antibody

RAD23B (1228CT409.120.123.135) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name120, 123, 135) Monoclonal Antibody, RAD23B (1228CT409
Also known as120, 123, 135) Monoclonal Antibody, RAD23B (1228CT409
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRAD23B
SpecificityThis is a highly specific antibody against RAD23B
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number120, 1228CT409, 123, 135
SourceThis RAD23B antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-409 amino acids from the N-terminal region of human RAD23B
Gene ID number5887
Swiss ProtP54727
Tested ApplicationsWB
Recommended dilutionsWB( 1:1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Binds to polyubiquitin chains, Cooperatively with CETN2 appears to stabilize XPC, Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation, Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair, Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex, May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome, May protect XPC from proteasomal degradation, Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome, RPA and the TFIIH complex, The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, The orientation of XPC complex binding appears to be crucial for inducing a productive NER, XPA, XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery, is part of the pre-incision (or initial recognition) complex, mismatched bubbles or single-stranded overhangs, Multiubiquitin chain receptor involved in modulation of proteasomal degradation
Purification method This antibody is purified through a protein G column, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names HHR23B, HR23B, RAD23B, UV excision repair protein RAD23 homolog B, XP-C repair-complementing complex 58 kDa protein, P58
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target120, 123, 135) Monoclonal, RAD23B (1228CT409
Short name120, 123, 135) Monoclonal Antibody, RAD23B (1228CT409
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name cerevisiae) (1228CT409, 120, 123, 135) monoclonal (Antibody to), RAD23 homolog B (S
Alternative techniqueantibodies
Alternative to gene target DNA damage recognition and biological process this GO :0000718 and nucleotide-excision repair, DNA damage removal and biological process this GO :0003684 and damaged DNA binding and molecular function this GO :0003697 and single-stranded DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006281 and DNA repair and biological process this GO :0006289 and nucleotide-excision repair and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007283 and spermatogenesis and biological process this GO :0031593 and polyubiquitin binding and molecular function this GO :0032434 and regulation of proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0043161 and proteasome-mediated ubiquitin-dependent protein catabolic process and biological process this GO :0071942 and XPC complex and cellular component, HHR23B and HR23B and P58, RAD23B and IDBG-637385 and ENSBTAG00000001926 and 530189, RAD23B and IDBG-79797 and ENSG00000119318 and 5887, Rad23b and IDBG-148611 and ENSMUSG00000028426 and 19359, cerevisiae), nuclei, polyubiquitin binding, this GO :0000502 and proteasome complex and cellular component this GO :0000715 and nucleotide-excision repair, this GO :0003684: damaged DNA binding, this GO :0003684: damaged DNA binding and also this GO :0003697: single-stranded DNA binding and also this GO :0005515: protein binding and also this GO :0031593: polyubiquitin binding, this GO :0003697: single-stranded DNA binding, this GO :0005515: protein binding, this GO :0031593: polyubiquitin binding, RAD23 homolog B (S
Identity 9813
Gene RAD23B
Long gene name RAD23 homolog B, nucleotide excision repair protein
Synonyms gene name RAD23 (S, cerevisiae) , cerevisiae) homolog B RAD23 homolog B (S
Synonyms HHR23B P58 HR23B
Synonyms name XP-C repair complementing protein XP-C repair complementing complex 58 kDa
Locus 9q31, 2
Discovery year 1994-07-20
Entrez gene record 5887
Pubmed identfication 7851894 8168482
RefSeq identity NM_002874
Classification Nucleotide excision repair
Havana BLAST/BLAT OTTHUMG00000020446

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