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RAD50 Antibody

RAD50 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameRAD50 Primary Polyclonal Antibody
Also known asRAD50 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRAD50
SpecificityThis is a highly specific antibody against RAD50
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range817-872/1312
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RAD50
Gene ID number10111
Swiss ProtQ92878
Tested ApplicationsWB
Recommended dilutionsWB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen DNA recombination, In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888), PubMed:9590181, PubMed:9651580), PubMed:9705271, RAD50 may be required to bind DNA ends and hold them in close proximity, The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416), The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:11741547, maintenance of telomere integrity and meiosis, which are provided by MRE11A, which plays a central role in double-strand break (DSB) repair, Component of the MRN complex
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names RAD50, hRAD50, DNA repair protein RAD50
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetRAD50
Short nameRAD50 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameRAD50 (Antibody to)
Alternative techniqueantibodies
Identity 9816
Gene RAD50
Long gene name RAD50 double strand break repair protein
Synonyms gene name RAD50 (S, cerevisiae) RAD50 homolog, cerevisiae) homolog RAD50 homolog (S, double strand break repair protein
Synonyms hRad50 RAD50-2
Locus 5q31, 1
Discovery year 1999-07-23
GenBank acession Z75311
Entrez gene record 10111
Pubmed identfication 8756642 9705271
RefSeq identity NM_005732
Classification BRCA1 C complex MRN complex
Havana BLAST/BLAT OTTHUMG00000059613

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