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RAD50 Antibody, Biotin Conjugated

RAD50 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, RAD50 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenRAD50
SpecificityThis is a highly specific antibody against RAD50
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range817-872/1312
Subcellular locationNucleus
SourceKLH conjugated synthetic peptide derived from human RAD50
Gene ID number10111
Swiss ProtQ92878
Tested applicationsWB
Recommended dilutionsWB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background DNA recombination, In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888), PubMed:9590181, PubMed:9651580), PubMed:9705271, RAD50 may be required to bind DNA ends and hold them in close proximity, The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416), The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:11741547, maintenance of telomere integrity and meiosis, which are provided by MRE11A, which plays a central role in double-strand break (DSB) repair, Component of the MRN complex
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms hRad50 RAD50-2
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetRAD50 Conjugated
Short name Conjugated, RAD50 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, RAD50 (Antibody to)
Alternative techniqueantibodies
Identity 9816
Gene RAD50
Long gene name RAD50 double strand break repair protein
Synonyms gene name RAD50 (S, cerevisiae) RAD50 homolog, cerevisiae) homolog RAD50 homolog (S, double strand break repair protein
Locus 5q31, 1
Discovery year 1999-07-23
GenBank acession Z75311
Entrez gene record 10111
Pubmed identfication 8756642 9705271
RefSeq identity NM_005732
Classification BRCA1 C complex MRN complex
Havana BLAST/BLAT OTTHUMG00000059613

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