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RAGE Antibody

RAGE Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameRAGE Primary Polyclonal Antibody
Also known asRAGE PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRAGE
SpecificityThis is a highly specific antibody against RAGE
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range140-190/402
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from rat AGER
Gene ID number81722
Swiss ProtQ63495
Tested Applications FCM, IF(IHC-P), IHC-P, WB
Recommended dilutions FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityRat
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen ABPP-initiated RAGE signaling, AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes, Can also bind oligonucleotides (By similarity), Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons, Interaction with S1A12 on endothelium, Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling, Receptor for amyloid beta peptide, These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes, and endothelial dysfunction in type 2 diabetes, and lymphocytes triggers cellular activation, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space, mononuclear phagocytes, oxidative stress, with generation of key proinflammatory mediators, Mediates interactions of advanced glycosylation end products (AGE)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Advanced glycosylation end product-specific receptor, Ager, Receptor for advanced glycosylation end products, RAGE
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetRAGE
Short nameRAGE Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameRAGE (Antibody to)
Alternative techniqueantibodies
Identity 320
Gene AGER
Long gene name advanced glycosylation end-product specific receptor
Synonyms RAGE SCARJ1
Synonyms name receptor for advanced glycation end-products
Locus 6p21, 32
Discovery year 1994-10-17
GenBank acession M91211
Entrez gene record 177
Pubmed identfication 7713518
RefSeq identity NM_001136
Classification C2-set domain containing Immunoglobulin like domain containing Scavenger receptors
Havana BLAST/BLAT OTTHUMG00000031120

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