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RAR alpha Antibody

RAR alpha Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameRAR alpha Primary Polyclonal Antibody
Also known asRAR alpha PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenRAR alpha
SpecificityThis is a highly specific antibody against RAR alpha
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range410-462/462
Subcellular location Nucleus, Cytoplasm
SourceOVA conjugated synthetic peptide derived from mouse Retinoic acid Receptor Alpha
Gene ID number19401
Swiss ProtP11416
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Has a role in the survival of early spermatocytes at the beginning prophase of meiosis, In Sertoli cells, In concert with RARG, In the absence of ligand, Mediates retinoic acid-induced granulopoiesis, On ligand binding, RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis, Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, chromatin condensation and transcriptional suppression, matrix homeostasis and growth plate function, may promote the survival and development of early meiotic prophase spermatocytes, required for skeletal growth, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation, Receptor for retinoic acid
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Nr1b1, Nuclear receptor subfamily 1 group B member 1, RAR-alpha, RARalpha1, Rara, Retinoic acid receptor alpha, RAR
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetRAR alpha
Short nameRAR alpha Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameRAR a (Antibody to)
Alternative techniqueantibodies
Identity 9864
Gene RARA
Long gene name retinoic acid receptor alpha
Synonyms gene name alpha , retinoic acid receptor
Synonyms RAR NR1B1
Locus 17q21, 2
Discovery year 1988-06-09
GenBank acession X06538
Entrez gene record 5914
Pubmed identfication 2825036 8244378
Classification Nuclear hormone receptors
Havana BLAST/BLAT OTTHUMG00000133328
Locus Specific Databases LRG_1070

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